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Interactive effects of phasic and tonic irritability and negative life events on internalizing symptoms: examining network connectivity

Award Number: F31MH143384
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 10/24/2026
PERIOD OF PERFORMANCE END DATE: 10/23/2027

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Interactive effects of phasic and tonic irritability and negative life events on internalizing symptoms: examining network connectivity - PROJECT SUMMARY/ABSTRACT Given that internalizing disorders are highly prevalent starting in childhood, understanding early risk factors for these symptoms is crucial for mitigating long-term negative effects on academic performance, social functioning, and overall quality of life. Two critical early risk factors—irritability and negative life events—are strongly linked to the development of internalizing disorders. Irritability is multifaceted, with both tonic (grouchy mood) and phasic (temper outburst) components. However, little is known regarding whether differential longitudinal interactions among phasic and tonic irritability and negative life events influence internalizing symptoms. Additionally, the neural mechanisms underlying these processes remain unknown. Since irritability is one of the primary reasons that children are brought in for psychiatric care, it is critical to understand if irritability’s two core facets (tonic and phasic) predict divergent symptom trajectories and to deepen our knowledge regarding the underlying pathophysiology that may influence these differences. Longitudinal work is thus needed to examine the distinct impact of phasic and tonic irritability on internalizing symptom trajectories in the context of negative life events, and to investigate associated neural substrates. This proposal will utilize data from the Adolescent Brain Cognitive Development (ABCD) Study, a longitudinal sample of over 11,000 youth followed from 9-15 years, with resting-state fMRI completed at two-year intervals, and measures of irritability, negative life events, and internalizing symptoms collected annually. Using linear mixed effect modeling, this study will examine the interactive effects of phasic and tonic irritability with negative life events on internalizing symptom trajectories (Aim 1). This project will also investigate the relationship between phasic and tonic irritability and network connectivity in the context of high negative life events over time, using longitudinal canonical correlation analysis (CCA) (Aim 2). This predoctoral fellowship award will bring together a team of experts in their respective fields and allow for the PI Archer to receive advanced training in developmental neuroscience, resting-state fMRI network connectivity analysis, and advanced quantitative methods. Together, the research project and training will provide the fellow with the opportunity to develop necessary skills for a productive career as a clinical scientist investigating how irritability’s adaptive and maladaptive features impact internalizing symptoms, with the hopes of informing the development of targeted and personalized interventions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $34,240 )
2026	2026	VANDERBILT UNIVERSITY	110 21ST AVE S	NASHVILLE	TN	37203	DAVIDSON	USA	Mental Health Research Grants	000	1	4/29/2026	NEW	$34,240
														Subtotal = $34,240

Grand Total All Awards = $34,240

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Interactive effects of phasic and tonic irritability and negative life events on internalizing symptoms: examining network connectivity

Award Number: F31MH143384

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 10/24/2026

PERIOD OF PERFORMANCE END DATE: 10/23/2027

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