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Optimizing in vivo dLight recordings for investigating the influence of disease on dopamine signaling.

Award Number: F31MH135696
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 04/01/2024
PERIOD OF PERFORMANCE END DATE: 09/30/2025

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Optimizing in vivo dLight recordings for investigating the influence of disease on dopamine signaling. - Project Summary This proposed research aims to provide a roadmap for studying dopamine dynamics using a novel optical tool, dLight, deepening our understanding of dopamine biology. Altered dopamine signaling is central to many neurological and neuropsychiatric disorders, yet we lack effective treatments for these disorders. Many existing treatments act on dopaminergic systems, but they act on slow time scales and do not work for all patients. Deepening our fundamental understanding of dopamine biology can lead to the discovery of improved treatments. The Tian lab developed dLight, which is an optical biosensor that can directly record dopamine signaling in vivo with high precision. The proposed work aims to determine the performance metrics of the newest dLight variants in vivo and use the sensor to measure alterations in dopamine activity in a disease model. Specifically, I will measure differences in dopamine signaling between offspring of the maternal immune activation model and healthy controls, as offspring from this model have been shown to have altered dopamine signaling systems. Additionally, I will create a database of the data collected to share with the neuroscience research community, increasing the accessibility of dLight and enabling researchers to use this novel tool in their own research. Successful completion of this project has the potential to transform our understanding of dopamine biology and significantly contribute to the development of effective treatments for many neurological and neuropsychiatric disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $25,755 )
2025	2025	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Mental Health Research Grants	000	2	3/11/2025	NON-COMPETING CONTINUATION	$25,755
														Subtotal = $25,755

Issue Date FY: 2024 ( Subtotal = $41,972 )
2024	2024	REDACTED DUE TO PII		DAVIS	CA	95618	YOLO	USA	Mental Health Research Grants	002	1	8/2/2024	NEW	$1,280
2024	2024	REDACTED DUE TO PII		DAVIS	CA	95618	YOLO	USA	Mental Health Research Grants	000	1	3/11/2024	NEW	$40,692
2024	2024	REDACTED DUE TO PII		DAVIS	CA	95618	YOLO	USA	Mental Health Research Grants	001	1	3/11/2024	NEW	$0
														Subtotal = $41,972

Grand Total All Awards = $67,727

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Optimizing in vivo dLight recordings for investigating the influence of disease on dopamine signaling.

Award Number: F31MH135696

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 04/01/2024

PERIOD OF PERFORMANCE END DATE: 09/30/2025

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