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The role of sexually dimorphic vasopressin in social behavior

Award Number: F31MH125659
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 02/22/2021
PERIOD OF PERFORMANCE END DATE: 06/21/2023

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The role of sexually dimorphic vasopressin in social behavior - Project Summary This project aims to understand the function of sex difference in the neural control of social behavior by focusing on the sexually dimorphic vasopressin system, where males have much higher vasopressin expression than females. Experiments proposed during the fellowship period will identify whether the sex difference in vasopressin innervation contributes to sex differences in the control of social behavior and communication. I will gain exceptional training in powerful genetic approaches that allow us to target vasopressin cells and the vasopressin gene specifically. The first aim tests whether excitation or inhibition of the sexually dimorphic vasopressin cells in the bed nucleus of the stria terminalis (BNST) affects social behavior differently in males and females. The second aim tests whether vasopressin is the key neuropeptide mediating sex-different effects on social communication observed in a previous study that ablated BNST vasopressin cells. This project will significantly enhance our mechanistic understanding of how the brain controls social behavior differently in males and females and may explain why many behavioral disorders show striking sex differences in morbidity. Although recently major advances have been made in understanding the neural basis of social behavior in adulthood, how such behavior is controlled differently in males and females is, by and large, unknown. This training grant will address these issues.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$49,553 )
2024	2023	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC	58 EDGEWOOD AVE NE	ATLANTA	GA	30303	FULTON	USA	Mental Health Research Grants	001	3	4/24/2024	NON-COMPETING CONTINUATION	-$27,323
2024	2022	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC	58 EDGEWOOD AVE NE	ATLANTA	GA	30303	FULTON	USA	Mental Health Research Grants	000	2	4/24/2024	NON-COMPETING CONTINUATION	-$22,230
														Subtotal = -$49,553

Issue Date FY: 2023 ( Subtotal = $27,323 )
2023	2023	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC	58 EDGEWOOD AVE NE	ATLANTA	GA	30303	FULTON	USA	Mental Health Research Grants	001	3	8/14/2023	NON-COMPETING CONTINUATION	-$20,371
2023	2023	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Mental Health Research Grants	000	3	2/10/2023	NON-COMPETING CONTINUATION	$47,694
														Subtotal = $27,323

Issue Date FY: 2022 ( Subtotal = $46,753 )
2022	2022	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Mental Health Research Grants	001	2	4/28/2022	NON-COMPETING CONTINUATION	$717
2022	2022	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Mental Health Research Grants	000	2	1/28/2022	NON-COMPETING CONTINUATION	$46,036
														Subtotal = $46,753

Issue Date FY: 2021 ( Subtotal = $46,036 )
2021	2021	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Mental Health Research Grants	001	1	1/22/2021	NEW	$0
2021	2021	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Mental Health Research Grants	000	1	1/22/2021	NEW	$45,520
2021	2021	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Mental Health Research Grants	002	1	4/7/2021	NEW	$516
														Subtotal = $46,036

Grand Total All Awards = $70,559

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The role of sexually dimorphic vasopressin in social behavior

Award Number: F31MH125659

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 02/22/2021

PERIOD OF PERFORMANCE END DATE: 06/21/2023

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