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Self-regulation of Prefrontal Cortex during Emotional Cognitive Control

Award Number: F31MH122090
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 04/01/2020
PERIOD OF PERFORMANCE END DATE: 07/31/2022

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Self-regulation of Prefrontal Cortex during Emotional Cognitive Control - PROJECT SUMMARY/ABSTRACT Deficits in emotional cognitive control are present in a number of clinical psychiatric populations including depression, anxiety, and PTSD. Deficits in this domain of function limit one's ability to focus attention on goal- directed activities while inhibiting reactions to irrelevant emotional stimuli, and this contributes to the symptoms of these disorders and makes individuals less likely to be successful in existing treatments. The left dorsolateral prefrontal cortex (LDLPFC) and its connectivity with other regions (i.e., dorsal anterior cingulate cortex, ventromedial prefrontal cortex, insula, amygdala) is thought to play a central role in facilitating emotional cognitive control. However, past research has primarily utilized correlational approaches that limit conclusions about the directionality of these relationships. Enhancing our understanding of the neural underpinnings of emotional cognitive control could be valuable for informing treatment for populations with deficits in these processes. The current study utilizes a neuromodulatory approach called real-time functional magnetic resonance imaging neurofeedback (rtfMRI-nf) whereby participants observe their own neural activity in the moment and are taught to self-regulate this activity. Healthy adult participants will be trained to increase neural activity in LDLPFC while involved in mental tasks involving emotional cognitive control processes. The mental tasks will include counting, remembering words, or planning events while viewing negatively-valenced emotional words (e.g., kill, death, threat). This study will use an experimental approach with participants being randomized to either LDLPFC rtfMRI-nf or control rtfMRI-nf where participants receive neural feedback from a region not involved with emotional cognitive control processes. Resting-state fMRI scans and behavioral testing sessions will take place before and after rtfMRI-nf. The specific aims are to examine the impact of LDLPFC rtfMRI-nf on: (1) LDLPFC activity during emotional cognitive control and (2) LDLPFC functional connectivity with other brain regions during rest. Additionally, this study will examine the neural correlates of emotional cognitive control independent of rtfMRI-nf. Thus, the final specific aim is to (3) Investigate relationships between individual differences in LDLPFC engagement, cognitive control performance, trauma history, and sleep quality. To facilitate the relevance of these findings to clinical populations, trauma exposure and sleep quality will be explored as moderators of neural change across time for those in the rtfMRI-nf group. To these ends, this study will use rtfMRI-nf to experimentally investigate the relationship between LDLPFC activity and emotional cognitive control as well as investigate these neural mechanisms independent of rtfMRI-nf. This research will improve our understanding of emotional cognitive control and demonstrate whether this is a modifiable target for intervention in populations with deficits in this domain of function. Future studies by the applicant could utilize LDLPFC rtfMRI- nf or other neuromodulatory approaches to modify neural activity and behavior in clinical populations, which could potentially lead to improved outcomes either as standalone or adjunctive treatment.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $11,207 )
2022	2022	UNIVERSITY OF TULSA, THE	800 S TUCKER DR	TULSA	OK	74104	TULSA	USA	Mental Health Research Grants	001	3	4/28/2022	NON-COMPETING CONTINUATION	$239
2022	2022	UNIVERSITY OF TULSA, THE	800 S TUCKER DR	TULSA	OK	74104	TULSA	USA	Mental Health Research Grants	000	3	3/11/2022	NON-COMPETING CONTINUATION	$10,968
														Subtotal = $11,207

Issue Date FY: 2021 ( Subtotal = $45,685 )
2021	2021	UNIVERSITY OF TULSA, THE	800 S TUCKER DR	TULSA	OK	74104	TULSA	USA	Mental Health Research Grants	001	2	3/26/2021	NON-COMPETING CONTINUATION	$15,649
2021	2021	UNIVERSITY OF TULSA, THE	800 S TUCKER DR	TULSA	OK	74104	TULSA	USA	Mental Health Research Grants	000	2	3/23/2021	NON-COMPETING CONTINUATION	$30,036
														Subtotal = $45,685

Issue Date FY: 2020 ( Subtotal = $44,725 )
2020	2020	UNIVERSITY OF TULSA, THE	800 S TUCKER DR	TULSA	OK	74104	TULSA	USA	Mental Health Research Grants	003	1	4/14/2020	NEW	$0
2020	2020	UNIVERSITY OF TULSA, THE	800 S TUCKER DR	TULSA	OK	74104	TULSA	USA	Mental Health Research Grants	002	1	4/14/2020	NEW	$504
2020	2020	UNIVERSITY OF TULSA, THE	800 S TUCKER DR	TULSA	OK	74104	TULSA	USA	Mental Health Research Grants	001	1	3/3/2020	NEW	$0
2020	2020	UNIVERSITY OF TULSA, THE	800 S TUCKER DR	TULSA	OK	74104	TULSA	USA	Mental Health Research Grants	000	1	3/3/2020	NEW	$44,221
														Subtotal = $44,725

Grand Total All Awards = $101,617

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Self-regulation of Prefrontal Cortex during Emotional Cognitive Control

Award Number: F31MH122090

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 04/01/2020

PERIOD OF PERFORMANCE END DATE: 07/31/2022

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