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Amygdalo-Striatal Contributions to Active Fear Responses

Award Number: F31MH098510
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 01/01/2013
PERIOD OF PERFORMANCE END DATE: 04/30/2013

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Amygdalo-Striatal Contributions to Active Fear Responses - DESCRIPTION (provided by applicant): Anxiety and depression are amongst the most prevalent psychiatric disorders, striking over 40 million new adults in the United States each year. However, therapeutic interventions are limited by our incomplete knowledge of the neural circuitry underlying aversive information processing. Although we know a great deal about how fear associations are acquired, and how they can produce more passive responses such as freezing, we know far less about how fear learning directs active behaviors that may help an animal escape or avoid dangerous situations. Both the basolateral amygdala (BLA) and nucleus accumbens (NAc) are known to be important for emotional learning and motivated behavior, but it is unknown how these structures work together to support active behavioral responses to aversive stimuli. We hypothesize that coordination of BLA and NAc neuronal activity allows active reorganization of behavior in response to aversive cues. To test this, we will use behavioral and electrophysiological techniques to explore 1) whether functional communication between the BLA and NAc is necessary to allow active reorganization or 'switching' of behavioral strategies and 2) how aversive cues that direct different types of behavioral outcomes are represented in firing patterns within the NAc and BLA. This work is expected to provide novel insight into the neural substrates underlying emotion and motivation, while providing advanced training in behavioral and electrophysiological methods in an exceptional environment. PUBLIC HEALTH RELEVANCE: Anxiety and depression are amongst the most prevalent psychiatric disorders in the United States, and typically involve dysregulation of motivational responses to emotionally-salient cues. This proposal addresses the fundamental mechanisms by which key neural circuits normally process such cues to appropriately organize behavioral responses. Success in this project would significantly advance our understanding of both normal and pathological emotional states.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = -$1 )
2017	2012	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Mental Health National Research Service Awards for Research Training	000	1	5/15/2017	NEW	-$1
														Subtotal = -$1

Issue Date FY: 2013 ( Subtotal = -$19,121 )
2013	2012	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Mental Health National Research Service Awards for Research Training	001	1	5/7/2013	NEW	-$2,333
2013	2012	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Mental Health National Research Service Awards for Research Training	000	1	5/3/2013	NEW	-$16,788
														Subtotal = -$19,121

Issue Date FY: 2012 ( Subtotal = $32,723 )
2012	2012	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Mental Health National Research Service Awards for Research Training	000	1	7/1/2012	NEW	$32,723
														Subtotal = $32,723

Grand Total All Awards = $13,601

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Amygdalo-Striatal Contributions to Active Fear Responses

Award Number: F31MH098510

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 01/01/2013

PERIOD OF PERFORMANCE END DATE: 04/30/2013

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