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Stress Coping and Prefrontal Connectivity

Award Number: F31MH094094
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 09/26/2011
PERIOD OF PERFORMANCE END DATE: 09/25/2013

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Stress Coping and Prefrontal Connectivity - DESCRIPTION (provided by applicant): This F31 application requests 3-years of funding to support my doctoral training and education in the use of multi-modal brain image processing methods to investigate stress coping-induced adaptations in prefrontal white matter connectivity. Coping with intermittent social stress is an essential aspect of living in complex social environments. Coping tends to counteract the deleterious effects of stress, and is thought to induce neuroadaptations in corticolimbic brain systems. The proposed research tests this hypothesis using an animal model of prefrontal growth and development. Aim 1. Confirm that early postnatal stress coping-induced changes in prefrontal white matter persist into mid-life adulthood. Based on results from my preliminary analysis, I hypothesize that prefrontal white matter volumes derived from T1-weighted anatomical images and fractional anisotropy determined by diffusion tensor imaging (DTI) will be greater in animals that have previously experienced and coped with postnatal social separations compared to non-separated controls. Aim 2. Determine whether postnatal stress coping increases prefrontal-amygdala connectivity determined by DTI. Tractography analysis of white mater tract densities as determined from DTI data will be used to test the hypothesis that prefrontal-amygdala white matter connectivity is increased in animals that have previously experienced and coped with postnatal social separations compared to non-separated controls. Aim 3. Determine whether stress coping-induced increases in prefrontal-amygdala structural connectivity correspond with increased functional connectivity. Resting-state functional magnetic resonance imaging (fMRI) data will be used to test the hypothesis that stress coping-induced increases in prefrontal-amygdala structural connectivity determined by DTI tractography correspond with increased functional connectivity in this corticolimbic network.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = -$595 )
2017	2012	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Mental Health National Research Service Awards for Research Training	000	2	5/15/2017	NON-COMPETING CONTINUATION	-$595
														Subtotal = -$595

Issue Date FY: 2013 ( Subtotal = -$1,012 )
2013	2012	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Mental Health National Research Service Awards for Research Training	000	2	8/29/2013	NON-COMPETING CONTINUATION	-$1,012
														Subtotal = -$1,012

Issue Date FY: 2012 ( Subtotal = $32,554 )
2012	2012	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Mental Health National Research Service Awards for Research Training	000	2	8/14/2012	NON-COMPETING CONTINUATION	$32,554
														Subtotal = $32,554

Issue Date FY: 2011 ( Subtotal = $32,122 )
2011	2011	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Mental Health National Research Service Awards for Research Training	001	1	7/28/2011	NEW	$32,122
2011	2011	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Mental Health National Research Service Awards for Research Training	000	1	7/28/2011	NEW	$0
														Subtotal = $32,122

Grand Total All Awards = $63,069

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Stress Coping and Prefrontal Connectivity

Award Number: F31MH094094

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 09/26/2011

PERIOD OF PERFORMANCE END DATE: 09/25/2013

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