Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

The Effect of Anticipation on Episodic Memory: Motivation and Attention

Award Number: F31MH092032
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 08/22/2011
PERIOD OF PERFORMANCE END DATE: 05/31/2013

Group Awards By:

View Award Description

The Effect of Anticipation on Episodic Memory: Motivation and Attention - DESCRIPTION (provided by applicant): Anticipatory goal-directed processes, such as attention and motivation, have a significant impact on learning and memory, yet much is still unknown about how such processes exert their influence in the human brain. Episodic memory-memory for specific events-critically relies on the integrity of the structures of the medial temporal lobe (MTL), including the hippocampus (CA fields, dentate gyrus, and subiculum) and parahippocampal gyrus (entorhinal, perirhinal and parahippocampal cortices). The MTL receives direct projections from brain regions involved in attention and reward-based motivation, including posterior parietal cortex (PPC), prefrontal cortex (PFC), and midbrain. Activation of these motivational and attentional networks prior to stimulus presentation may influence memory formation by facilitating stimulus processing within the MTL. The research presented in this proposal will use functional magnetic resonance imaging (fMRI) to examine how goal-directed processes initiated prior to stimulus presentation recruit attentional and motivational brain networks and influence memory formation in the MTL. Experiment 1 will use high-resolution fMRI to test the hypothesis that reward-based motivation differentially affects MTL subregional function through interactions with midbrain structures. We will examine whether motivational incentives that elicit activation from dopaminergic midbrain prior to stimulus presentation enhance memory encoding within MTL subregions. Experiment 2 will test the hypothesis that attentional cues can bias MTL processing and facilitate memory formation. We will examine if anticipatory cues that indicate task-relevant goals elicit activation from PPC, PFC, and task-relevant MTL subregions prior to stimulus presentation, and whether this results in enhanced episodic encoding. Experiment 3 will examine the effects of reward-based motivation on associative memory formation under conditions of full and divided attention to test the hypothesis that motivation drives MTL-based memory formation through allocation of attentional resources. By increasing understanding of memory function within the MTL, this work has the ability to shed light on changes in MTL structure and function known to occur in normal aging and mental illnesses, including Alzheimer's disease, depression, bipolar disorder and schizophrenia. The proposed research examines how interactions between dopaminergic midbrain and MTL influence memory, which will provide insight into disorders that involve disruptions of the DA system, including Parkinson's disease, depression, bipolar disorder, and schizophrenia. This work may prove particularly informative for understanding the MTL dysfunction and impairments in memory and attention that occur in schizophrenia.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = -$117 )
2017	2012	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR, MN 13	AUSTIN	TX	78712	TRAVIS	USA	Mental Health National Research Service Awards for Research Training	000	2	5/15/2017	NON-COMPETING CONTINUATION	-$117
														Subtotal = -$117

Issue Date FY: 2013 ( Subtotal = -$4,915 )
2013	2012	UNIVERSITY OF TEXAS AT AUSTIN	P.O. BOX 7159	AUSTIN	TX	78713	TRAVIS	USA	Mental Health National Research Service Awards for Research Training	000	2	7/22/2013	NON-COMPETING CONTINUATION	-$4,915
														Subtotal = -$4,915

Issue Date FY: 2012 ( Subtotal = $32,277 )
2012	2012	UNIVERSITY OF TEXAS AT AUSTIN	P.O. BOX 7159	AUSTIN	TX	78713	TRAVIS	USA	Mental Health National Research Service Awards for Research Training	000	2	7/11/2012	NON-COMPETING CONTINUATION	$32,277
														Subtotal = $32,277

Issue Date FY: 2011 ( Subtotal = $31,845 )
2011	2011	UNIVERSITY OF TEXAS AT AUSTIN	P.O. BOX 7159	AUSTIN	TX	78713	TRAVIS	USA	Mental Health National Research Service Awards for Research Training	001	1	7/26/2011	NEW	$31,845
2011	2011	UNIVERSITY OF TEXAS AT AUSTIN	P.O. BOX 7159	AUSTIN	TX	78713	TRAVIS	USA	Mental Health National Research Service Awards for Research Training	000	1	7/26/2011	NEW	$0
														Subtotal = $31,845

Grand Total All Awards = $59,090

Top

All Categories

About

Search

Reports

Data Submission

Award Information

The Effect of Anticipation on Episodic Memory: Motivation and Attention

Award Number: F31MH092032

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 08/22/2011

PERIOD OF PERFORMANCE END DATE: 05/31/2013

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer