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Pattern Analysis of Large-Scale Functional Connectivity in SAD

Award Number: F31MH088104
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 06/07/2010
PERIOD OF PERFORMANCE END DATE: 06/06/2013

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Pattern Analysis of Large-Scale Functional Connectivity in SAD - The current proposal is aimed at developing a novel neurobiological marker based on patterns of whole-brain functional connectivity during implicit and subliminal threat-related facial emotion perception to aid the diagnosis and assessment of treatment response in social anxiety (SAD) and panic disorder (PD). The following Specific Aims are proposed: Specific Aim 1). Develop, apply and validate an approach to estimate the large-scale functional networks of implicit and subliminal threat-related and ambiguous facial emotion processing in a healthy control subject pool. We will perform this by first testing whether large-scale partial correlations measured during a particular condition (i.e. presentation of visible or invisible fearful and neutral faces) can be used as features to predict the stimulus type presented during the condition (Sub-aim 1a). We will then test whether the most informative features for predicting fearful vs. neutral face conditions are connections among primarily limbic and paralimbic nodes, and that the most informative features in predicting neutral vs. resting states conditions are connections among primarily attention, motor and sensory related regions (Sub-aim 1b). Specific Aim 2). Determine whether the approach developed in SA1 may have potential clinical application towards the diagnosis and treatment of SAD and PD. We will perform this by testing whether the above functional networks are informative brain signatures that can be used to discriminate between healthy controls, SAD and PD subjects (Sub-aim 2a). We will also test whether the approach can be used to determine the particular sub-networks that are aberrant in SAD and PD (Sub-aim 2b).


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2012	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Mental Health National Research Service Awards for Research Training	000	3	5/15/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2012 ( Subtotal = $38,180 )
2012	2012	COLUMBIA UNIVERSITY	615 WEST 131ST ST, 4TH FLOOR	NEW YORK	NY	10027	NEW YORK	USA	Mental Health National Research Service Awards for Research Training	000	3	4/19/2012	NON-COMPETING CONTINUATION	$38,180
														Subtotal = $38,180

Issue Date FY: 2011 ( Subtotal = $37,400 )
2011	2011	COLUMBIA UNIVERSITY	615 WEST 131ST ST, 4TH FLOOR	NEW YORK	NY	10027	NEW YORK	USA	Mental Health National Research Service Awards for Research Training	000	2	5/4/2011	NON-COMPETING CONTINUATION	$37,400
														Subtotal = $37,400

Issue Date FY: 2010 ( Subtotal = $36,642 )
2010	2010	COLUMBIA UNIVERSITY	615 WEST 131ST ST, 4TH FLOOR	NEW YORK	NY	10027	NEW YORK	USA	Mental Health Research Grants	000	1	5/28/2010	NEW	$36,642
2010	2010	COLUMBIA UNIVERSITY	615 WEST 131ST ST, 4TH FLOOR	NEW YORK	NY	10027	NEW YORK	USA	Mental Health Research Grants	001	1	5/28/2010	NEW	$0
														Subtotal = $36,642

Grand Total All Awards = $112,222

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Pattern Analysis of Large-Scale Functional Connectivity in SAD

Award Number: F31MH088104

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 06/07/2010

PERIOD OF PERFORMANCE END DATE: 06/06/2013

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