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Designing Implementation Strategies to Improve Adoption and Uptake of Low-Dose Aspirin for Pre-eclampsia Prevention.

Award Number: F31HL186636
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 01/17/2027
PERIOD OF PERFORMANCE END DATE: 01/16/2028

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Designing Implementation Strategies to Improve Adoption and Uptake of Low-Dose Aspirin for Pre-eclampsia Prevention. - PROJECT SUMMARY/ABSTRACT Hypertensive disorders during pregnancy, particularly pre-eclampsia, represent a leading cause of maternal and perinatal mortality worldwide. Despite compelling evidence that low-dose aspirin is a safe, low-cost, and effective intervention for pre-eclampsia prevention in moderate- to high-risk pregnancies, its uptake remains highly variable globally, leaving many at-risk women without access to this life-saving therapy. This F31 proposal leverages innovative approaches to advance the field of maternal health implementation research by addressing a critical gap through the application of co-design methodology, which directly involves patients and community stakeholders and builds on existing research partnerships with investigators in Nepal to identify factors and explore strategies to improve implementation of low-dose aspirin for pre-eclampsia prevention. We are using the Capability, Opportunity, Motivation, and Behavior (COM-B) framework to collect and analyze data obtained by qualitative interviews with healthcare providers (n=45, ongoing) and pregnant women (n=36, completed) to explore the barriers and facilitators influencing their capability, opportunity, and motivation to prescribe and use low-dose aspirin, respectively (Aim 1). In Aim 2, key barriers and facilitators will be prioritized with stakeholders to co-design implementation strategies. Finally, we will assess hospital site capacity to integrate low-dose aspirin into routine care by using data that will be collected by administering the theory-based Organizational Readiness to Change Assessment (ORCA) tool to one hospital administrator and one clinical provider each in a pilot sample of 8-10 hospitals (Aim 3). The findings from this project will serve as the foundation for a future implementation trial to evaluate the effectiveness of the co-designed strategies, with the potential to influence the broader global health landscape. Insights gained will be valuable not only for Nepal but could also inform recommendations for pre-eclampsia prevention in other countries, including the United States, where hypertensive disorders in pregnancy continue to pose a significant public health challenge. Completion of this mentored research project combined with relevant training opportunities in a strong research training environment will contribute to the F31 applicants goals to gain: a) skills in qualitative data analysis, b) expertise in developing context specific implementation strategies, c) implementation science trial design, and d) scientific communication and development as an independent researcher able to conduct mixed-methods implementation science to inform the prevention and management of diseases disproportionately affecting women and children globally. This project aligns with the National Heart, Lung, and Blood Institute's (NHLBI) mission and priority area to advance translational research that improves health and reduces disease and supports priority initiatives such as the Maternal Health Community Implementation Program (MH-CIP), which aims to implement and scale evidence-based maternal health interventions to improve pregnancy and postpartum outcomes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $50,114 )
2026	2026	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	1	7/24/2026	NEW	$50,114
														Subtotal = $50,114

Grand Total All Awards = $50,114

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Designing Implementation Strategies to Improve Adoption and Uptake of Low-Dose Aspirin for Pre-eclampsia Prevention.

Award Number: F31HL186636

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 01/17/2027

PERIOD OF PERFORMANCE END DATE: 01/16/2028

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