Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Accelerated dual-venc 5D flow to capture respiration-driven hemodynamic biomarkers of RV dysfunction in Tetralogy of Fallot

Award Number: F31HL184660
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 12/29/2026
PERIOD OF PERFORMANCE END DATE: 12/28/2027

Group Awards By:

View Award Description

Accelerated dual-venc 5D flow to capture respiration-driven hemodynamic biomarkers of RV dysfunction in Tetralogy of Fallot - Project Summary Tetralogy of Fallot (TOF) is a severe form of congenital heart disease that affect over 1600 babies in the United States per year. These patients are at risk of right ventricular (RV) failure and other life-threatening complications due to pulmonary valve regurgitation that persists even after the initial surgical treatment. Within 35 years of initial surgery, many patients require a pulmonary valve replacement intervention to prevent severe RV remodeling, but currently mortality is not improved after intervention. The guidelines surrounding intervention are unclear and variable because the mechanisms of RV remodeling are not well-characterized in the pediatric TOF population. A number of studies have shown that 4D flow MRI can measure altered efficiency in 3D RV flow patterns that are associated with adverse outcomes in TOF, indicating the potential of including biomarkers of blood flow dynamics and efficiency in the mechanistic understanding of RV remodeling in these patients. Pulmonary regurgitation changes over the respiratory cycle, with increases in regurgitation when chest pressure increases during expiration. 4D flow can only capture a small part of the respiratory cycle, so respiration-related information on flow efficiency is not included in these potential biomarkers. 5D flow MRI was introduced to capture flow over the respiratory cycle, but it currently cannot be used to capture a high dynamic range of velocities, such as those in TOF, in a clinically feasible scan time. The goal of this project is to develop accelerated dual-venc 5D flow (increasing the dynamic range with a short scan time) to measure flow efficiency over respiration in TOF patients and identify novel respiration-resolved biomarkers of RV remodeling. The first aim of this proposal is the development and validation of accelerated dual-venc 5D flow MRI with a novel acquisition and reconstruction method to achieve a target <8-minute scan time and clinical ease of use. Testing and validation will be performed first in a pulsatile flow phantom with realistic cardiac flow rates and then with 10 healthy volunteers. The second aim is to acquire accelerated 5D flow MRI in 30 TOF patients recruited from the patient population at Lurie Children's Hospital and measure 3D biomarker of flow efficiency over the respiratory cycle to determine how they may differ from healthy dynamics, how they may be associated with clinical indicators of RV remodeling, and whether respiration-resolved biomarkers can better discriminate patients with poor clinical status. Clinical collaborators will help guide the project to fulfil the ultimate goal of improving pediatric clinical imaging and analysis of these complex patients. Siemens support will help with technical development and deployment on MRI scanners, so that this project can be easily integrated in future studies and clinical workflows.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $45,888 )
2026	2026	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cardiovascular Diseases Research	000	1	7/7/2026	NEW	$45,888
														Subtotal = $45,888

Grand Total All Awards = $45,888

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Accelerated dual-venc 5D flow to capture respiration-driven hemodynamic biomarkers of RV dysfunction in Tetralogy of Fallot

Award Number: F31HL184660

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 12/29/2026

PERIOD OF PERFORMANCE END DATE: 12/28/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer