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Mechanisms Contributing to Functional Recovery across the Care Cascade for Respiratory Failure

Award Number: F31HL182272
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 09/03/2025
PERIOD OF PERFORMANCE END DATE: 09/02/2027

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Mechanisms Contributing to Functional Recovery across the Care Cascade for Respiratory Failure - PROJECT SUMMARY Respiratory failure is a life-threatening condition affecting millions of individuals in the United States annually. Although mortality rates for respiratory failure have decreased, survivors frequently experience persistent physical impairments and decreased quality of life. Little is known about how factors experienced across the course of critical illness, such as receipt of specific care processes (e.g., early mobilization) or post-discharge setting (e.g., neighborhood environment) influence functional recovery and quality of life. To identify targets for intervention on disparities in recovery from respiratory failure, it is critical to examine the sequential impact of social determinants before hospitalization, care processes during hospitalization, and living environments following hospitalization. The goal of the proposed research is to generate evidence to inform interventions promoting recovery of function following hospitalization with respiratory failure. The central hypothesis of this proposal is that patient-level social determinants, unit-level care processes, and community-level environmental factors produce disparities in long-term outcomes among survivors of respiratory failure. In this research, the applicant aims to: 1) examine the influence of social determinants recorded at hospital admission on functional recovery over time among survivors of respiratory insufficiency and failure; 2) characterize the barriers to providing early mobilization in two high-volume medical intensive care units (MICU); and 3) evaluate the influence of neighborhood environments on long-term recovery among survivors of respiratory failure. The proposed research will take place at New York University (NYU), which provides a robust research infrastructure that supports proposal development and fosters research engagement among NYU faculty and students. Training goals throughout the fellowship award include (1) build advanced methodological skills in state-of- the-art longitudinal modeling techniques applied to complex real-word data; (2) advance capabilities in qualitative data collection and analysis using gold-standard methods from the social sciences and implementation science; (3) develop analytical skills in Bayesian analysis; (4) develop a comprehensive knowledge of key theories, frameworks, and concepts that explain health disparities; (5) strengthen skills in scientific writing and dissemination; and (6) study and practice the responsible conduct of research. Mentorship and supervision from Sponsor, Co-Sponsors, and Contributor will occur regularly throughout the fellowship award to augment all aspects of training. The F31 will also provide crucial protected time to advance toward the goal of a productive career as an independent research career as an epidemiologist of function.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $53,114 )
2026	2026	NEW YORK UNIVERSITY	70 WASHINGTON SQ S FL 11	NEW YORK	NY	10012	NEW YORK	USA	Lung Diseases Research	000	2	9/2/2026	NON-COMPETING CONTINUATION	$53,114
														Subtotal = $53,114

Issue Date FY: 2025 ( Subtotal = $49,538 )
2025	2025	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Lung Diseases Research	000	1	9/3/2025	NEW	$49,538
2025	2025	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Lung Diseases Research	001	1	9/3/2025	NEW	$0
														Subtotal = $49,538

Grand Total All Awards = $102,652

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Mechanisms Contributing to Functional Recovery across the Care Cascade for Respiratory Failure

Award Number: F31HL182272

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 09/03/2025

PERIOD OF PERFORMANCE END DATE: 09/02/2027

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