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Uncovering Molecular Cues Regulating Response to Injury in the Adult Zebrafish Heart

Award Number: F31HL182175
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 01/01/2027
PERIOD OF PERFORMANCE END DATE: 12/31/2027

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Uncovering Molecular Cues Regulating Response to Injury in the Adult Zebrafish Heart - Abstract: The adult zebrafish is capable of rapid regenerative processes in response to cardiac damage that result in a fully functional and scarless heart. This robust regenerative response is controlled by pre-existing populations of cardiomyocytes that de-differentiate prior to proliferation in response to injury; however, the full extent of intercellular signaling that facilitates the injury-response of these cardiomyocytes remains unknown. A subpopulation of cardiomyocytes in the zebrafish heart are derived from the cardiac neural crest (CNC), a highly migratory stem cell population in the early vertebrate embryo. These neural crest-derived cardiomyocytes (NCCMs) may contribute extensively to regeneration in the adult heart by reactivating developmental gene networks, including those controlling morphogenesis in the early embryo. In particular, the cxcr4b/cxcl12a chemokine signaling pathway is known to be essential for CNC migration in the developing embryo and regulates aspects of migration in the regenerating heart. To assess the roles of cxcr4b/cxcl12a in relation to the CNC during cardiac regeneration in the adult, I will conduct mRNA expression and localization analyses via hybridization chain reaction (HCR), in vitro migration assays of primary cardiomyocyte cultures, and create transgenic fish lines for the conditional overexpression and knockout of cxcl12a and cxcr4b, respectively, during cardiac regeneration in the adult. I will also analyze existing cardiac ATAC-seq data to identify and validate putative damage-responsive enhancer regions that drive chemokine gene expression. Identifying how migratory mechanisms guide cardiomyocytes will assist in discovering therapeutic approaches aimed at stimulating human hearts with a regenerative capacity.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $44,262 )
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	119 CALIFORNIA HALL	BERKELEY	CA	94720	ALAMEDA	USA	Cardiovascular Diseases Research	000	1	7/7/2026	NEW	$44,262
														Subtotal = $44,262

Grand Total All Awards = $44,262

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Uncovering Molecular Cues Regulating Response to Injury in the Adult Zebrafish Heart

Award Number: F31HL182175

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 01/01/2027

PERIOD OF PERFORMANCE END DATE: 12/31/2027

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