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Evaluating the association of sleep variability on measures of cardiovascular health in females at different stages of life

Award Number: F31HL181943
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 12/02/2026
PERIOD OF PERFORMANCE END DATE: 12/01/2027

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Evaluating the association of sleep variability on measures of cardiovascular health in females at different stages of life - Abstract: The proposed research aims to investigate the relationship between sleep variability and cardiovascular (CV) health markers in pre- and postmenopausal females. Sleep variability, characterized by irregular sleep duration and timing, is a recognized risk factor for hypertension (HTN) and cardiovascular disease (CVD). Historically, there has been a lack of female representation in sleep and circadian research, with majority of research focused on males and mixed-gender samples, despite evidence indicating sex differences in circadian rhythms and sleep health. Circadian rhythms are endogenous patterns that control a range of CV process such as, blood pressure (BP) and vascular function across an approximate 24hr cycle. Variable sleep patterns can disrupt these internal rhythms causing alterations in 24-hr BP patterns, vascular function, and autonomic BP responses to exercise, which are all associated with increased risk for CV events and disease. However, sex-aggerated data complicates the interpretation and generalization of previous findings. Thus, investigations targeted at characterizing the impact of sleep variability on BP, vascular function, and the autonomic regulation of BP are needed, specifically in females. The overall goal of this F31 research proposal is to investigate how varying levels of sleep variability relate to 24-hr BP, vascular function, and autonomic BP regulation in females at different stages of life. This proposal will foster the development of new proficiencies and technical skills in areas of cardiac baroreflex sensitivity via beat-by-beat BP assessment, and macro- and microvascular function via Doppler ultrasound, to support the investigator in achieving their long-term goal of investigating the effects of acute and chronic sleep disruptions on CV health outcomes. In order to achieve the overall goal, this proposal encompasses three specific aims. Aim 1 seeks to determine if high sleep variability is associated with decreased cardiac baroreflex sensitivity and increased BP reactivity to sympathoexcitatory stimuli in premenopausal females. Aims 2 and 3 investigate whether high sleep variability is linked to reduced vascular function and elevated 24-hr BP patterns in both premenopausal females and postmenopausal females with HTN. The central hypothesis is that increased sleep variability will be associated with poor CV health (i.e., 24-hr ambulatory BP, vascular function, and autonomic regulation of BP) in different life stages. These studies are innovative, in their use of novel concepts related to sleep variability and CV health in healthy and elevated CVD risk females, including postmenopausal females with HTN. The proposed research is significant because it will improve our understanding of 1) the underlying sympathetic reflexes associated with sleep variability in premenopausal females and 2) assess the association of sleep variability on vascular health in pre- and postmenopausal females with HTN.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $50,114 )
2026	2026	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 360	EAST LANSING	MI	48824	INGHAM	USA	National Center on Sleep Disorders Research	000	1	6/2/2026	NEW	$50,114
														Subtotal = $50,114

Grand Total All Awards = $50,114

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Evaluating the association of sleep variability on measures of cardiovascular health in females at different stages of life

Award Number: F31HL181943

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 12/02/2026

PERIOD OF PERFORMANCE END DATE: 12/01/2027

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