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Association of Stressful Life Experiences Reported During Pregnancy with Cardiovascular Disease Risk in Mothers.

Award Number: F31HL178223
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 01/06/2025
PERIOD OF PERFORMANCE END DATE: 01/05/2027

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Association of Stressful Life Experiences Reported During Pregnancy with Cardiovascular Disease Risk in Mothers. - Cardiovascular disease (CVD) is the leading cause of death for women in the US. Pregnancy is a key sensitive period for CVD risk during which rapid maternal cardiovascular changes occur. There is evidence that adverse pregnancy outcomes (e.g., hypertensive disorders of pregnancy) significantly predict future maternal CVD risk. Stressors during pregnancy may have lasting implications for maternal CVD risk, as greater stress before and during pregnancy are associated with adverse pregnancy outcomes. However, little research has examined the associations of stressful life experiences before and during pregnancy with later maternal CVD risk. The proposed research examines associations of stressful life experiences during pregnancy with maternal CVD risk at 3-4 years postpartum, and evaluates whether childhood experiences increase vulnerability to these effects. This study uses a prospective longitudinal design including a population of at least 200 mothers enrolled in an ongoing longitudinal study (R01MH109662, R01HL155744). Stressful life experiences, ACEs, and PCEs were assessed during pregnancy, and maternal CVD risk is assessed in the lab at 3-4 years postpartum. This project has three aims, to test the hypotheses that: Aim 1: Greater stressful life experiences during pregnancy is associated with greater overall maternal CVD risk (Framingham-based CVD risk prediction model) at 3-4 years postpartum. Aim 2: Stressful life experiences during pregnancy is associated with increases in individual maternal CVD risk factors (BMI, waist circumference, body fat percentage, BP, and arterial stiffness) at 3-4 years postpartum. Aim 3 (Exploratory): Both higher adverse and fewer positive childhood experiences in mothers will increase vulnerability to the effect of stressful life experiences during pregnancy on later maternal CVD risk at 3-4 years postpartum. During the fellowship period, the applicant will gain essential training at the University of Denver that supports her goal of becoming an independent NIH-funded researcher. The applicant’s goals include developing 1) understanding of the perinatal period as a sensitive period for maternal health; 2) conceptual/methodological knowledge of perinatal and maternal cardiovascular health; 3) expertise in the influences of stressors and resilience factors on biological and behavioral pathways to CVD risk; 4) advanced skills in statistical and longitudinal analysis; and 5) skills in grant-writing. The completion of these training objectives, along with the strong mentorship will support this applicant’s goal of becoming an independent researcher.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $52,538 )
2026	2026	UNIVERSITY OF DENVER	2199 S UNIVERSITY BLVD RM 222	DENVER	CO	80210	DENVER	USA	Cardiovascular Diseases Research	000	2	3/27/2026	NON-COMPETING CONTINUATION	$52,538
														Subtotal = $52,538

Issue Date FY: 2025 ( Subtotal = $52,538 )
2025	2025	UNIVERSITY OF DENVER	2199 S UNIVERSITY BLVD RM 222	DENVER	CO	80210	DENVER	USA	Cardiovascular Diseases Research	002	1	9/16/2025	NEW	$564
2025	2025	UNIVERSITY OF DENVER	2199 S UNIVERSITY BLVD RM 222	DENVER	CO	80210	DENVER	USA	Cardiovascular Diseases Research	001	1	1/3/2025	NEW	$0
2025	2025	UNIVERSITY OF DENVER	2199 S UNIVERSITY BLVD RM 222	DENVER	CO	80210	DENVER	USA	Cardiovascular Diseases Research	000	1	1/3/2025	NEW	$51,974
														Subtotal = $52,538

Grand Total All Awards = $105,076

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Association of Stressful Life Experiences Reported During Pregnancy with Cardiovascular Disease Risk in Mothers.

Award Number: F31HL178223

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 01/06/2025

PERIOD OF PERFORMANCE END DATE: 01/05/2027

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