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Loss of myeloid Paired Immunoglobulin-like Receptor B promotes atherosclerosis through inhibition of autophagy and metabolic rewiring

Award Number: F31HL170766
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 05/01/2024
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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Loss of myeloid Paired Immunoglobulin-like Receptor B promotes atherosclerosis through inhibition of autophagy and metabolic rewiring - PROJECT SUMMARY Cardiovascular disease (CVD) is the leading cause of death globally. The root cause of CVD is a chronic inflammatory disease of the arterial wall called atherosclerosis. A critical determinant of atherosclerosis is macrophage inflammatory phenotype. Within atherosclerosis, anti-inflammatory pathways are dysfunctional, which results in pro-inflammatory stimuli driving macrophage phenotype. We have identified Paired immunoglobulin-like receptor B (PirB) as a novel inhibitor of macrophage-mediated inflammation by facilitating apoptotic cell digestion and promoting mitochondrial function. The aims of this proposal will determine the mechanisms by which PirB inhibits inflammation through phagosomal and mitochondrial signaling pathways. We will use macrophages containing a lysosomal reporter to track phagosome maturation and cargo fate. Additionally, we will dissect the molecular mechanism by which PirB regulates mitochondrial metabolic function and signaling.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $34,859 )
2025	2025	VANDERBILT UNIVERSITY	110 21ST AVE S	NASHVILLE	TN	37203	DAVIDSON	USA	Cardiovascular Diseases Research	000	2	6/27/2025	NON-COMPETING CONTINUATION	$34,859
														Subtotal = $34,859

Issue Date FY: 2024 ( Subtotal = $34,295 )
2024	2024	VANDERBILT UNIVERSITY	110 21ST AVE S	NASHVILLE	TN	37203	DAVIDSON	USA	Cardiovascular Diseases Research	001	1	8/31/2024	NEW	$1,280
2024	2024	VANDERBILT UNIVERSITY	110 21ST AVE S	NASHVILLE	TN	37203	DAVIDSON	USA	Cardiovascular Diseases Research	002	1	8/31/2024	NEW	$0
2024	2024	VANDERBILT UNIVERSITY	110 21ST AVE S	NASHVILLE	TN	37203	DAVIDSON	USA	Cardiovascular Diseases Research	000	1	4/8/2024	NEW	$33,015
														Subtotal = $34,295

Grand Total All Awards = $69,154

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Loss of myeloid Paired Immunoglobulin-like Receptor B promotes atherosclerosis through inhibition of autophagy and metabolic rewiring

Award Number: F31HL170766

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 05/01/2024

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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