Thursday, March 13, 2025 3/13/2025

Free-living and in-lab effects of sedentary time on cardiac autonomic nervous system function in youth with overweight/obesity

Award Number: F31HL164032
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

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PROJECT ABSTRACT Cardiovascular disease (CVD) is a significant public health burden and remains the leading cause of mortality among the U.S population. CVD progression can originate during childhood, and youth with overweight and obesity (OW/OB) have an increased risk for CVD development. One mechanism that contributes to the development of CVD is imbalanced cardiac autonomic nervous system (ANS) function. The cardiac ANS governs the heart’s response to everyday conditions via sympathetic and parasympathetic modulation, in which balance of the sympathetic and parasympathetic systems indicates healthy cardiac ANS function. However, youth with OW/OB present overactivation of the sympathetic modulation of the heart, which is strongly associated with several adverse health outcomes. Studies in youth demonstrated that increased sedentary time (ST) is related to higher CVD risk. However, it is unknown whether the associations between ST and CVD are due to time displaced from physical activity to ST or due to underlying physiological processes stimulated by ST. Reduced cardiac ANS balance may be mediating the ST and CVD risk association, but few researchers have examined the associations between ST and cardiac ANS function, and none have examined associations within a day or within a person, and have not experimentally manipulated prolonged ST. Understanding the relationship of ST to cardiac ANS function may provide insight toward methodologies to alleviate CVD development, especially in youth with OW/OB who are at significantly higher risk for CVD. This project aims to leverage data collection opportunities from the NIH-funded Sedentary Breaks Study 3 (P.I. Dr. Britni Belcher; R01DK12333) to elucidate observational and experimental relationships between ST and cardiac ANS function via measures of heart rate variability in youth with OW/OB. The first phase of this project will investigate daily associations between objectively-measured ST and cardiac ANS function under habitual conditions. In the second phase, this project will have an innovative experimental component to determine the acute effects of interrupting ST on cardiac ANS function in-lab over seven consecutive days among three conditions: 1) continuous sitting (SIT), 2) sitting interrupted by 3-minute bouts of moderate-intensity walking every 30 minutes (SIT+WALK), and 3) sitting interrupted by a single 18-minute bout of moderate-intensity walking (EX).


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $47,874 )
2025	2025	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Cardiovascular Diseases Research	000	3	12/19/2024	NON-COMPETING CONTINUATION	$47,874
														Subtotal = $47,874

Issue Date FY: 2024 ( Subtotal = $47,874 )
2024	2024	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Cardiovascular Diseases Research	001	2	8/29/2024	NON-COMPETING CONTINUATION	$1,280
2024	2024	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Cardiovascular Diseases Research	000	2	12/14/2023	NON-COMPETING CONTINUATION	$46,594
														Subtotal = $47,874

Issue Date FY: 2023 ( Subtotal = $46,594 )
2023	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Cardiovascular Diseases Research	002	1	4/1/2023	NEW	$0
2023	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Cardiovascular Diseases Research	001	1	4/1/2023	NEW	$942
2023	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Cardiovascular Diseases Research	000	1	12/23/2022	NEW	$45,652
														Subtotal = $46,594

Grand Total All Awards = $142,342

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Free-living and in-lab effects of sedentary time on cardiac autonomic nervous system function in youth with overweight/obesity

Award Number: F31HL164032

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

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