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Identification of chemosensitive cells within the lateral hypothalamus

Award Number: F31HL160191
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 09/01/2021
PERIOD OF PERFORMANCE END DATE: 12/15/2024
AWARD TERMINATION DATE: 03/27/2026

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Identification of chemosensitive cells within the lateral hypothalamus - PROJECT SUMMARY Respiratory chemoreception is the mechanism by which the brain regulates breathing in response to changes in CO2/H+. This mechanism is essential for maintaining breathing unconsciously and its disruption is associated with breathing problems particularly during sleep. The lateral hypothalamus has long been considered a chemoreceptor region; however, mechanisms underlying this function are poorly understood. As LHA neurons show considerable genetic variability that may correlate with function, my central hypothesis is that discrete subsets of LHA neurons are specialized to function as respiratory chemoreceptors. To test this, I will use a novel genetic approach to label and identify CO2/H+ activated LHA neurons (Aim 1); identify intrinsic and synaptic mechanisms contributing to LHA CO2/H+ sensitivity (Aim 2), and determine contributions of these cells to baseline breathing and the ventilatory response to CO2 (Aim 3). Important outcomes of this work include 1) determining the cellular and network basis for how the LHA contributes to the CO2/H+ dependent breath, 2) inform about LHA functional heterogeneity, and 3) provide valuable training in molecular, cellular and whole animal approaches that should make me well positioned for taking the next step towards my goal of becoming an independent investigator.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$22,367 )
2026	2024	UNIVERSITY OF CONNECTICUT	438 WHITNEY RD EXTENSION UNIT 1133	STORRS	CT	06269	CAPITOL	USA	National Center on Sleep Disorders Research	000	4	3/27/2026	TERMINATION	-$22,367
														Subtotal = -$22,367

Issue Date FY: 2024 ( Subtotal = $44,945 )
2024	2024	UNIVERSITY OF CONNECTICUT	438 WHITNEY RD EXTENSION UNIT 1133	STORRS	CT	06269	CAPITOL	USA	National Center on Sleep Disorders Research	000	4	8/30/2024	NON-COMPETING CONTINUATION	$44,945
														Subtotal = $44,945

Issue Date FY: 2023 ( Subtotal = $43,665 )
2023	2023	UNIVERSITY OF CONNECTICUT	438 WHITNEY RD EXTENSION UNIT 1133	STORRS	CT	06269	CAPITOL	USA	National Center on Sleep Disorders Research	000	3	8/3/2023	NON-COMPETING CONTINUATION	$43,665
														Subtotal = $43,665

Issue Date FY: 2022 ( Subtotal = $42,723 )
2022	2022	UNIVERSITY OF CONNECTICUT	438 WHITNEY RD EXTENSION UNIT 1133	STORRS	CT	06269	CAPITOL	USA	National Center on Sleep Disorders Research	002	2	8/10/2022	NON-COMPETING CONTINUATION	$42,723
2022	2021	UNIVERSITY OF CONNECTICUT	438 WHITNEY RD EXTENSION UNIT 1133	STORRS	CT	06269	CAPITOL	USA	National Center on Sleep Disorders Research	001	1	2/10/2022	NEW	$0
2022	2021	UNIVERSITY OF CONNECTICUT	438 WHITNEY RD EXTENSION UNIT 1133	STORRS	CT	06269	CAPITOL	USA	National Center on Sleep Disorders Research	000	1	2/10/2022	NEW	$0
														Subtotal = $42,723

Issue Date FY: 2021 ( Subtotal = $42,007 )
2021	2021	UNIVERSITY OF CONNECTICUT	438 WHITNEY RD EXTENSION UNIT 1133	STORRS	CT	06269	CAPITOL	USA	National Center on Sleep Disorders Research	000	1	8/11/2021	NEW	$42,007
														Subtotal = $42,007

Grand Total All Awards = $150,973

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Identification of chemosensitive cells within the lateral hypothalamus

Award Number: F31HL160191

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 09/01/2021

PERIOD OF PERFORMANCE END DATE: 12/15/2024

AWARD TERMINATION DATE: 03/27/2026

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