Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

EMBLEM - Epigenetic Mapping by Labeled Exploration of Modifications

Award Number: F31HG015217
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 06/23/2027
PERIOD OF PERFORMANCE END DATE: 06/22/2028

Group Awards By:

View Award Description

EMBLEM - Epigenetic Mapping by Labeled Exploration of Modifications - Project Summary: The regulation of gene expression is governed by an intricate epigenomic code—layers of DNA modifications, protein–DNA interactions, chromatin accessibility, and higher-order genome architecture—that act in concert to control when and where genes are activated. Disruption of this code underlies many diseases, yet our understanding of how its components coordinate across long genomic distances and through time remains incomplete, particularly within heterogeneous cell populations. Existing methods typically profile one feature at a time and rely on short-read sequencing, fragmenting the view of regulatory landscapes and obscuring combinatorial and long-range interactions, such as those between enhancers and promoters or the co-occurrence of activating and repressive histone marks on the same molecule. To address these gaps, I will develop EMBLEM (Epigenetic Mapping by Labeled Exploration of Modifications)—a multiplexed, single-molecule platform combining exogenous labeling with long-read sequencing to decode epigenomic regulation in space and time. By integrating targeted labeling of histone modifications, chromatin accessibility, and protein–DNA interactions with native DNA methylation detection, EMBLEM will directly “write” regulatory information onto DNA molecules and “read” it back during sequencing. This approach will enable me to (1) resolve bivalent chromatin dynamics at single-molecule resolution, (2) map long-range regulatory interactions spanning kilobases, and (3) define the temporal choreography of epigenomic remodeling during transcriptional reprogramming. The resulting tools and open-source analysis pipelines will provide an unprecedented, molecule-by-molecule view of the epigenome, advancing our ability to investigate how heterogeneous regulatory states drive cell fate decisions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $50,114 )
2026	2026	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Human Genome Research	000	1	9/22/2026	NEW	$50,114
														Subtotal = $50,114

Grand Total All Awards = $50,114

Top

All Categories

About

Search

Reports

Data Submission

Award Information

EMBLEM - Epigenetic Mapping by Labeled Exploration of Modifications

Award Number: F31HG015217

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 06/23/2027

PERIOD OF PERFORMANCE END DATE: 06/22/2028

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer