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Force transmission through Cell–Cell and Cell–Matrix interactions in a bilayered epithelium during Wound Healing

Award Number: F31HD123983
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 09/01/2026
PERIOD OF PERFORMANCE END DATE: 08/31/2031

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Force transmission through Cell–Cell and Cell–Matrix interactions in a bilayered epithelium during Wound Healing - Project Summary Wound healing requires the collective migration of cells to close gaps in tissues and maintain barrier function. Prior studies using single-layered epithelia demonstrated that during wound closure, tissues generate forward- moving forces by deforming the underlying matrix. In the skin, the underlying matrix is the basement membrane, a specialized extracellular matrix that anchors the epithelium. However, it is unclear how multilayered epithelia like the skin close wounds given their native basement membrane composition and complex interactions. This proposal aims to define the roles of cell–cell and cell–matrix adhesions in coordinating forces in a multilayered epithelium during wound closure. It utilizes the embryonic zebrafish skin as genetically tractable two-layered epithelium suitable for live imaging. Additionally, the proposed experimental design combines a novel tool to deplete proteins in a tissue-specific manner, with a method to measure traction forces in vivo. Together, these methods offer a powerful way to link molecular mechanisms to mechanical outputs that are necessary for wound closure. Ultimately, this research aims to provide a comprehensive understanding of wound closure in vivo, informing therapeutic strategies for diseases featuring chronic wounds.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $50,114 )
2026	2026	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Child Health and Human Development Extramural Research	000	1	8/11/2026	NEW	$50,114
2026	2026	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Child Health and Human Development Extramural Research	001	1	8/11/2026	NEW	$0
2026	2026	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Child Health and Human Development Extramural Research	002	1	8/31/2026	NEW	$0
														Subtotal = $50,114

Grand Total All Awards = $50,114

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Force transmission through Cell–Cell and Cell–Matrix interactions in a bilayered epithelium during Wound Healing

Award Number: F31HD123983

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 09/01/2026

PERIOD OF PERFORMANCE END DATE: 08/31/2031

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