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Understanding and Controlling the Cellular Forces that Coordinate Epithelial Tissue Morphogenesis

Award Number: F31HD105405
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

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Project Summary / Abstract Mechanical forces generated by the cellular actomyosin cytoskeleton are largely responsible for shaping sheets of epithelial cells into tissues and organs. During these morphogenetic events, the forces produced by myosin might locally promote or resist these shape changes. Our current understanding of how the structure of a myosin network influences tissue fluidity, the propensity of a tissue to remodel and flow, is lacking. In particular, it is not well understood why some epithelial cell sheets remodel and flow like fluids, while other stretch and bend like elastic solids, or how this is regulated during specific morphogenetic events. The goal of this project is to combine nanoengineering and optogenetic techniques to measure and manipulate tissues with high spatiotemporal precision to undercover the roles of actomyosin forces in tissue fluidity and morphogenesis. I will address these challenges by (1) studying myosin networks and tissue fluidity during convergent extension in Drosophila melanogaster, (2) quantitatively analyzing the forces generated by epithelial tissue sheets in vitro on nanofabricated substrates, and (3) applying these findings to tissues grown on a nanomaterial flexible substrate in an attempt to synthetically reconstitute and study three-dimensional tissue morphogenesis. These studies will improve our understanding of the mechanisms underlying how cells collectively self-organize and how perturbations in these mechanisms can lead to disease states.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $47,694 )
2023	2023	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	202 LOW LIBRARY 535 W 116 ST MC 4309,	NEW YORK	NY	10027	NEW YORK	USA	Child Health and Human Development Extramural Research	000	3	8/25/2023	NON-COMPETING CONTINUATION	$47,694
														Subtotal = $47,694

Issue Date FY: 2022 ( Subtotal = $46,752 )
2022	2022	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	202 LOW LIBRARY 535 W 116 ST MC 4309,	NEW YORK	NY	10027	NEW YORK	USA	Child Health and Human Development Extramural Research	000	2	8/1/2022	NON-COMPETING CONTINUATION	$46,752
														Subtotal = $46,752

Issue Date FY: 2021 ( Subtotal = $46,036 )
2021	2021	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	116TH AND BDWY	NEW YORK	NY	10027	NEW YORK	USA	Child Health and Human Development Extramural Research	000	1	4/12/2021	NEW	$46,036
2021	2021	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	116TH AND BDWY	NEW YORK	NY	10027	NEW YORK	USA	Child Health and Human Development Extramural Research	001	1	4/12/2021	NEW	$0
														Subtotal = $46,036

Grand Total All Awards = $140,482

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Understanding and Controlling the Cellular Forces that Coordinate Epithelial Tissue Morphogenesis

Award Number: F31HD105405

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

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