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In vivo structural-based quantitative modeling of aqueous outflow dynamics in glaucomatous eyes

Award Number: F31EY039690
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 09/21/2026
PERIOD OF PERFORMANCE END DATE: 09/20/2031

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In vivo structural-based quantitative modeling of aqueous outflow dynamics in glaucomatous eyes - Project Summary Glaucoma is the global leading cause of irreversible blindness. It is an insidious often asymptomatic, neurodegenerative ocular disease that, if left untreated, can result in complete loss of visual perception. This makes early detection of glaucoma a critical focus of research in ophthalmology. Once diagnosed, disease progression can be slowed using a variety of effective treatment strategies, all of which aim to reduce intraocular pressure (IOP). Elevated IOP is the leading risk factor resulting from a defective aqueous humor outflow (AHO) mechanism. Current standard clinical treatment for glaucoma consists of eye drops, selective laser trabulectomy (SLT), and filtration surgeries, all of which aim to facilitate egress of aqueous from the eye’s anterior chamber into the blood stream until a lower, target IOP is achieved. These therapies can vary in success and longevity in both lowering IOP and slowing down disease progression. Despite treatment mechanisms targeting AHO cellular and structural components, in vivo AHO morphology is not fully understood, in health or disease. This knowledge gap is at least in part due to limited visibility of AHO and a lack of quantitative analysis tools. The overall goal of this thesis is to establish a morphological framework for the AHO system in healthy and glaucomatous eyes in live people. The strategy is an integrative approach, combining in vivo anterior segment optical coherence tomography (AS-OCT) imaging with advanced image processing, deep learning (DL) and computational modeling based on outflow facility to describe the AHO pathway morphology in healthy and glaucomatous eyes. By characterizing the three-dimensional (3D) architecture of key AHO structures and evaluating its changes under various disease states, this study will establish a comprehensive in vivo model of the AHO system for the first time, paving the way for improved knowledge of glaucoma pathophysiology and potential novel treatment outcome measures for improved glaucoma care. The overarching hypothesis is that detectable structural differences within the AHO pathway can be observed in the AHO structure between healthy and glaucoma using comprehensive in vivo modeling, enabling personalized outcome measures, progression tracking, and additional discrimination between health and disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $52,570 )
2026	2026	CITY OF PHILADELPHIA TRUSTEE UNDER THE WILL OF JAMES WILLS	840 WALNUT ST	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Vision Research	000	1	8/31/2026	NEW	$52,570
2026	2026	CITY OF PHILADELPHIA TRUSTEE UNDER THE WILL OF JAMES WILLS	840 WALNUT ST	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Vision Research	001	1	8/31/2026	NEW	$0
														Subtotal = $52,570

Grand Total All Awards = $52,570

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In vivo structural-based quantitative modeling of aqueous outflow dynamics in glaucomatous eyes

Award Number: F31EY039690

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 09/21/2026

PERIOD OF PERFORMANCE END DATE: 09/20/2031

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