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Linking endoplasmic reticulum calcium handling to neuronal function in vivo in the Drosophila visual system

Award Number: F31EY035165
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 12/16/2023
PERIOD OF PERFORMANCE END DATE: 12/15/2026

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Linking endoplasmic reticulum calcium handling to neuronal function in vivo in the Drosophila visual system - Project Summary Calcium (Ca2+) is a critical regulator of neurotransmission in both axons and dendrites of neurons. Ca2+ fluctuations during neuronal activation are usually attributed to influx through voltage gated Ca2+ channels, but in vitro evidence suggests that intracellular Ca2+ handling, particularly by the endoplasmic reticulum (ER), could shape cytosolic Ca2+ signals and therefore neurotransmission. Our preliminary data indicate that the ER in neurons of the Drosophila visual system displays Ca2+ fluctuations in response to visual stimulus in vivo. Given that altered ER Ca2+ signaling has been implicated in neurodegeneration and retinal degeneration, the objective of this work is to determine the role of ER Ca2+ signaling in Drosophila visual system neurons and determine the molecular basis of compartment specific ER Ca2+ signals in motion vision circuits. The first aim is to determine the underlying mechanisms governing compartment specific ER Ca2+ signals using in vivo 2-photon microscopy. Findings from this aim will help elucidate the functional roles of ER Ca2+ signals in axons and dendrites. The second aim is to determine the role of ER Ca2+ handling neurotransmission and in motion vision circuit function, leveraging genetic perturbations in well-defined circuits. These studies will determine if ER Ca2+ signaling shapes cytosolic Ca2+ fluctuations, linking it to circuit function and neurotransmission in the visual system. The fellowship training plan includes in vivo 2-photon imaging, Drosophila genetics, programming, and career guidance. Through training opportunities during this project, I will develop the skills to complete this work, and continue in a career in academic research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $43,138 )
2026	2026	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	615 W 131ST ST	NEW YORK	NY	10027	NEW YORK	USA	Vision Research	001	3	1/29/2026	NON-COMPETING CONTINUATION	$43,138
2026	2025	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	615 W 131ST ST	NEW YORK	NY	10027	NEW YORK	USA	Vision Research	000	2	12/17/2025	OTHER REVISION	$0
														Subtotal = $43,138

Issue Date FY: 2025 ( Subtotal = $43,138 )
2025	2025	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	615 W 131ST ST	NEW YORK	NY	10027	NEW YORK	USA	Vision Research	002	2	7/30/2025	OTHER REVISION	$564
2025	2025	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	615 W 131ST ST	NEW YORK	NY	10027	NEW YORK	USA	Vision Research	003	2	8/8/2025	OTHER REVISION	$0
2025	2025	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	615 W 131ST ST	NEW YORK	NY	10027	NEW YORK	USA	Vision Research	000	2	11/29/2024	NON-COMPETING CONTINUATION	$42,574
2025	2025	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	615 W 131ST ST	NEW YORK	NY	10027	NEW YORK	USA	Vision Research	001	2	3/17/2025	TERMINATION	$0
														Subtotal = $43,138

Issue Date FY: 2024 ( Subtotal = $42,574 )
2024	2024	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	615 W 131ST ST	NEW YORK	NY	10027	NEW YORK	USA	Vision Research	003	1	6/28/2024	NEW	$1,280
2024	2024	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	615 W 131ST ST	NEW YORK	NY	10027	NEW YORK	USA	Vision Research	001	1	12/12/2023	NEW	$0
2024	2024	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	615 W 131ST ST	NEW YORK	NY	10027	NEW YORK	USA	Vision Research	000	1	12/12/2023	NEW	$41,294
2024	2024	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	615 W 131ST ST	NEW YORK	NY	10027	NEW YORK	USA	Vision Research	002	1	1/17/2024	NEW	$0
														Subtotal = $42,574

Grand Total All Awards = $128,850

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Linking endoplasmic reticulum calcium handling to neuronal function in vivo in the Drosophila visual system

Award Number: F31EY035165

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 12/16/2023

PERIOD OF PERFORMANCE END DATE: 12/15/2026

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