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Investigating a pathogenic role for CD36-mediated Ly6C(lo) monocyte lipid-loading in diabetic kidney disease.

Award Number: F31DK138756
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 01/21/2025
PERIOD OF PERFORMANCE END DATE: 01/21/2026

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Investigating a pathogenic role for CD36-mediated Ly6C(lo) monocyte lipid-loading in diabetic kidney disease. - A. PROJECT SUMMARY Diabetic dyslipidemia, characterized by elevated triglyceride-rich lipoproteins (TRLs), is a known risk factor for renal function decline. At the same time, macrophage and lipid-loaded macrophage (foam cell) accumulation has been observed in kidney biopsies in individuals with diabetic kidney disease (DKD). Murine studies have demonstrated that reducing the accumulation of macrophages in the glomerulus halts the progression of DKD. Data from our laboratory indicates that reducing TRLs reduces DKD concomitant with an improvement in circulating lipid-loaded monocytes and the accumulation of lipid-loaded macrophages in the setting of diabetes. It remains unclear if and how diabetic dyslipidemia drives increased monocyte lipid loading in circulation and whether foam cells play a pathogenic role in DKD. In this study, we propose to study the mechanism by which circulating monocytes become lipid-loaded in diabetes and if blocking the pathway for monocyte lipid-loading reduces DKD. Exciting preliminary data demonstrate that a subset of monocytes in circulation, Ly6Clo monocytes, display increased expression of the scavenger receptor CD36 in diabetes, which corresponds with elevated Ly6Clo monocyte lipid-loading, and that this is in part mediated by hyperglycemia. The overall goal of this study is to investigate if the CD36 receptor mediates lipid uptake in circulating Ly6Clo monocytes in diabetes and contributes to foam cell formation in glomerular lesions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$44,813 )
2026	2025	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	12/10/2025	NEW	-$44,813
														Subtotal = -$44,813

Issue Date FY: 2025 ( Subtotal = $44,813 )
2025	2025	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	7/21/2025	NEW	$44,813
														Subtotal = $44,813

Grand Total All Awards = $0

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Investigating a pathogenic role for CD36-mediated Ly6C(lo) monocyte lipid-loading in diabetic kidney disease.

Award Number: F31DK138756

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 01/21/2025

PERIOD OF PERFORMANCE END DATE: 01/21/2026

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