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Evaluating the Role of Human Obesity Genes in Specific Neuronal Populations in vivo by CRISPRi

Award Number: F31DK137538
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 12/01/2024
PERIOD OF PERFORMANCE END DATE: 11/30/2026

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Evaluating the Role of Human Obesity Genes in Specific Neuronal Populations in vivo by CRISPRi - PROJECT ABSTRACT Obesity leads to an increased risk for type 2 diabetes, heart attack, hypertension, stroke, and many types of cancer—conditions which are among the leading causes of death in the US. Through twin and family studies, obesity has been found to have a 40-70% heritability rate, pointing to a strong genetic etiology. The long-term objective of our studies is to determine how genetic variation predisposes humans to obesity and the accompanying therapeutic implications. Here we are optimizing the development of a state-of-the-art approach based on CRISPR-mediated gene downregulation in a temporally, anatomically and cell-type specific manner, to rapidly test whether genes in which variation predisposes to obesity are required for the function of specialized neurons in the mouse hypothalamus. We will also be using this approach to test the hypothesis that genes in which mutations cause obesity by affecting the function of the primary cilia, a cell surface projection that receives and transduces select intercellular signals, are required for the function of neurons of central leptin-melanocortin system in mice.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $46,047 )
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	12/18/2025	NON-COMPETING CONTINUATION	$46,047
														Subtotal = $46,047

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	1	7/9/2025	OTHER REVISION	$0
2025	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	4/29/2025	TERMINATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $45,483 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	1	4/30/2024	NEW	$0
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	4/30/2024	NEW	$45,483
														Subtotal = $45,483

Grand Total All Awards = $91,530

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Evaluating the Role of Human Obesity Genes in Specific Neuronal Populations in vivo by CRISPRi

Award Number: F31DK137538

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 12/01/2024

PERIOD OF PERFORMANCE END DATE: 11/30/2026

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