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NS1 PROTEIN OF H5N1 DISRUPTS EPITHELIAL BARRIER OF THE GUT AND LUNG

Award Number: F31DK082270
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 07/01/2008
PERIOD OF PERFORMANCE END DATE: 05/31/2010

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NS1 PROTEIN OF H5N1 DISRUPTS EPITHELIAL BARRIER OF THE GUT AND LUNG - DESCRIPTION (provided by applicant): These studies aim to accomplish three major goals: first to define how the structural and functional integrity of the epithelial barrier is disrupted by NS1; second, to identify specific interacting partners of NS1; and third, to define NS1 as a novel drug target that can be used to contain the H5N1 pandemic. The specific aims of this proposal are Aim 1: To test the hypothesis that NS1 disrupts barrier function of gut and lung epithelial cells, and Aim 2: To test the hypothesis that the PDZ motif of NS1 protein binds tight junction proteins and adherens junction proteins. These studies will use the following techniques: transepithelial resistance measuremets, inulin flux measurements, immunofluorescent staining, cell migration assays, and protein binding studies. Influenza virus H5N1 has the potential to become a global pandemic and has already claimed 204 lives worldwide. These studies will contribute to public health by allowing us to understand the role of the NS1 protein of H5N1 in disease pathogenesis and to identify NS1 as a target for novel drug therapies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2010 ( Subtotal = -$1,748 )
2010	2009	UNIVERSITY OF TENNESSEE CENTER FOR THE HEALTH SCIENCES	62 SOUTH DUNLAP STREET	MEMPHIS	TN	38103	SHELBY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	8/9/2010	NON-COMPETING CONTINUATION	-$1,748
														Subtotal = -$1,748

Issue Date FY: 2009 ( Subtotal = $29,939 )
2009	2009	UNIVERSITY OF TENNESSEE CENTER FOR THE HEALTH SCIENCES	62 SOUTH DUNLAP STREET	MEMPHIS	TN	38103	SHELBY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	2	6/30/2009	NON-COMPETING CONTINUATION	$29,939
2009	2008	UNIVERSITY OF TENNESSEE CENTER FOR THE HEALTH SCIENCES	62 SOUTH DUNLAP STREET	MEMPHIS	TN	38103	SHELBY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	1	4/3/2009	NEW	$0
2009	2008	UNIVERSITY OF TENNESSEE CENTER FOR THE HEALTH SCIENCES	62 SOUTH DUNLAP STREET	MEMPHIS	TN	38103	SHELBY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	1	2/19/2009	NEW	$29,735
2009	2008	UNIVERSITY OF TENNESSEE CENTER FOR THE HEALTH SCIENCES	62 SOUTH DUNLAP STREET	MEMPHIS	TN	38103	SHELBY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	2/13/2009	NEW	-$29,735
														Subtotal = $29,939

Issue Date FY: 2008 ( Subtotal = $29,735 )
2008	2008	UNIVERSITY OF TENNESSEE	WEST CUMBERLAND AVENUE, SW	KNOXVILLE	TN	37916	KNOX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	6/30/2008	NEW	$29,735
														Subtotal = $29,735

Grand Total All Awards = $57,926

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NS1 PROTEIN OF H5N1 DISRUPTS EPITHELIAL BARRIER OF THE GUT AND LUNG

Award Number: F31DK082270

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 07/01/2008

PERIOD OF PERFORMANCE END DATE: 05/31/2010

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