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Investigating craniofacial phenotypes, cellular function, and membrane biochemistry of ciliary proteins Rsg1 and the Fam92-Chibby-Dzip module

Award Number: F31DE033290
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 09/01/2023
PERIOD OF PERFORMANCE END DATE: 08/31/2025

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Investigating craniofacial phenotypes, cellular function, and membrane biochemistry of ciliary proteins Rsg1 and the Fam92-Chibby-Dzip module - Abstract: Craniofacial differences are among the most common congenital disorders in humans. There are many regulatory factors at play during development of the head and face, with much left to understand. The dysfunction of the ciliogenesis and planar polarity effectors (CPLANE) are a known cause of human Orofaciodigital Disorders (OFD). The Rsg1 subunit of CPLANE is essential for ciliary function, but it remains among the least-studied components, and its mechanisms of action remain largely unexplored. Importantly, my preliminary data suggest that Rsg1 interacts with Fam92, Chibby, and Dzip1, proteins required for basal body docking and transition zone assembly. In this proposed research, the craniofacial developmental differences after disruption of Rsg1 and Fam92 will be explored in a model animal, with a specific focus on neural crest development. In vivo live imaging of ciliated cells will be studied to determine the cellular function of these proteins. Lastly, the biochemical function of the Fam92 BAR domains and disordered regions for membrane morphology will be explored in in vitro systems. Thus, the whole embryo, cellular, and biochemical functions of ciliary proteins Rsg1 and the Fam92- Chibby-Dzip1 module will be elucidated by the proposed work, which in turn will advance our understanding of congenital craniofacial disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $40,494 )
2024	2024	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Oral Diseases and Disorders Research	001	2	8/12/2024	NON-COMPETING CONTINUATION	$40,494
2024	2023	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Oral Diseases and Disorders Research	000	1	11/3/2023	NEW	$0
														Subtotal = $40,494

Issue Date FY: 2023 ( Subtotal = $39,214 )
2023	2023	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Oral Diseases and Disorders Research	001	1	8/22/2023	NEW	$0
2023	2023	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Oral Diseases and Disorders Research	000	1	8/22/2023	NEW	$39,214
														Subtotal = $39,214

Grand Total All Awards = $79,708

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Investigating craniofacial phenotypes, cellular function, and membrane biochemistry of ciliary proteins Rsg1 and the Fam92-Chibby-Dzip module

Award Number: F31DE033290

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 09/01/2023

PERIOD OF PERFORMANCE END DATE: 08/31/2025

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