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Characterizing the neuronal diversity of rapid activity in the olfactory bulb with a high speed two-photon microscope

Award Number: F31DC023782
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 09/10/2026
PERIOD OF PERFORMANCE END DATE: 09/09/2028

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Characterizing the neuronal diversity of rapid activity in the olfactory bulb with a high speed two-photon microscope - PROJECT SUMMARY Mice rely on precise spatiotemporal patterns of neural activity in the olfactory bulb (OB) to rapidly detect and discriminate odors. Two major output neuron types—mitral cells (MCs) and tufted cells (TCs)—are thought to form parallel pathways divergently optimized for downstream processing. These pathways are vital to the mammalian olfactory system, yet their precise functional roles remain ambiguous. While electrophysiological recordings have highlighted distinct response properties specific to each cell type, population-level dynamics specific to MCs and TCs have been elusive due to the limited temporal resolution of standard imaging technologies. This project seeks to elucidate the role of neuronal diversity in the OB by leveraging an innovative high-speed two-photon microscopy platform capable of capturing images of neural activity with high temporal resolution (400-1000 Hz). The frame rates afforded by this new microscope allow for two-photon voltage imaging to be carried out in OB projection neurons. Specific Aim 1 will establish and benchmark a voltage imaging platform for MC and TC populations by comparing candidate voltage indicators and optimizing imaging parameters such as frame rate, field of view, and illumination power against benchmarks for signal-to-noise ratio and population yield. Specific Aim 2 will apply high-speed imaging, and voltage indicators where feasible, to determine how MC and TC populations differ in sniff-cycle locking and odor-concentration coding in awake mice. These experiments will bring new temporal resolution and spatial throughput to bear on the hypothesis that TCs preferentially convey earlier, more concentration-invariant odor information, whereas MCs contribute more strongly to later, concentration-dependent temporal dynamics. This work will clarify how parallel olfactory output pathways support rapid sensory coding while also establishing a powerful framework for high-speed voltage imaging in the mammalian brain.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $50,114 )
2026	2026	NEW YORK UNIVERSITY	70 WASHINGTON SQ S FL 11	NEW YORK	NY	10012	NEW YORK	USA	Research Related to Deafness and Communication Disorders	001	1	9/10/2026	NEW	$0
2026	2026	NEW YORK UNIVERSITY	70 WASHINGTON SQ S FL 11	NEW YORK	NY	10012	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	1	9/10/2026	NEW	$50,114
														Subtotal = $50,114

Grand Total All Awards = $50,114

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Characterizing the neuronal diversity of rapid activity in the olfactory bulb with a high speed two-photon microscope

Award Number: F31DC023782

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 09/10/2026

PERIOD OF PERFORMANCE END DATE: 09/09/2028

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