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Serotonergic Modulation of Auditory Cortical Circuits

Award Number: F31DC023141
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 09/30/2026
PERIOD OF PERFORMANCE END DATE: 09/29/2027

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Serotonergic Modulation of Auditory Cortical Circuits - PROJECT SUMMARY Auditory experience exerts powerful influence on the functional organization of the developing auditory cortex (ACtx), but this plasticity declines into adulthood. However, robust plasticity can be reinstated in the adult by the release of neuromodulators, which can be leveraged to facilitate recovery from neurological disorders or peripheral hearing loss. How distinct neuromodulators act within cortex to drive plasticity, however, remains to be fully elucidated. For example, serotonin (5-HT) modulates cortical plasticity, but the underlying cellular and circuit mechanisms are unknown. Previous research, including our own, has identified serotonergic axons throughout the ACtx and localized 5-HT receptor mRNA to specific excitatory pyramidal and GABAergic inhibitory interneurons. Based on this distribution of 5-HT receptor subtypes, we hypothesize that 5-HT differentially modulates classes of inhibitory interneurons, which could broadly impact auditory cortical network activity. Combining whole-cell electrophysiology and two-photon imaging in mouse auditory thalamocortical slices, we will 1) determine the cellular and synaptic effects of 5-HT on cortical inhibitory interneurons, and 2) characterize the network effects of 5-HT on thalamic-evoked ACtx activity. The results of this research will provide insights into how 5-HT modulates auditory cortical circuits, which may be used to inform the development of targeted strategies to enhance adult plasticity.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $38,328 )
2026	2026	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	1	4/2/2026	NEW	$38,328
														Subtotal = $38,328

Grand Total All Awards = $38,328

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Serotonergic Modulation of Auditory Cortical Circuits

Award Number: F31DC023141

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 09/30/2026

PERIOD OF PERFORMANCE END DATE: 09/29/2027

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