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The genomic and synaptic basis of language disorder and learned sound association

Award Number: F31DC022183
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 09/01/2024
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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The genomic and synaptic basis of language disorder and learned sound association - Project Summary/Abstract Language disorder is a neurodevelopmental condition that occurs in ~7% of children starting school (Tomblin et al., 1997; Norbury et al., 2016). It has high comorbidity with autism spectrum disorder (ASD) (Ellis Weismer, 2013) and other impairments (Mueller and Tomblin, 2012; Snowling et al., 2020), which makes it challenging to identify its unique genomic and synaptic mechanisms. The focus of this proposal is to apply computational genomics and behavioral neuroscience to study language disorder in the context of learned sound association, the process by which the auditory nervous system associates a sound with a certain outcome (Stanley, 2023; Stanley et al., 2024). In Aim 1, I will use genome-wide association studies (GWAS) and post-GWAS analysis methods to conduct a large-scale analysis of the variants, genes, and pathways involved in language disorder and identify shared and distinct genetic factors between language disorder and ASD using human genetic data from the Genetics of Language (GenLang) consortium, the Simons Foundation Powering Autism Research (SPARK) dataset, the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort, and the United Kingdom (UK) Biobank. In Aim 2, I will conduct behavioral sound association experiments with wildtype (WT) and mutant mouse models using an interactive virtual reality (VR) environment, where mice will be trained to associate auditory cues with rewarding/aversive stimuli. Neuronal activity will be measured using fiber photometry recordings in the tail of the striatum. The comparison of human genetic data from Aim 1 with mouse physiology and behavioral data in Aim 2 will identify the timing and role for language disorder/ASD-linked genes in sound association learning and its disruption in neurodevelopmental disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $50,114 )
2026	2026	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	615 W 131ST ST	NEW YORK	NY	10027	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	3	8/18/2026	NON-COMPETING CONTINUATION	$50,114
														Subtotal = $50,114

Issue Date FY: 2025 ( Subtotal = $49,538 )
2025	2025	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	615 W 131ST ST	NEW YORK	NY	10027	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	2	8/6/2025	NON-COMPETING CONTINUATION	$49,538
														Subtotal = $49,538

Issue Date FY: 2024 ( Subtotal = $48,974 )
2024	2024	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	615 W 131ST ST	NEW YORK	NY	10027	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	1	8/20/2024	NEW	$48,974
2024	2024	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	615 W 131ST ST	NEW YORK	NY	10027	NEW YORK	USA	Research Related to Deafness and Communication Disorders	001	1	8/20/2024	NEW	$0
														Subtotal = $48,974

Grand Total All Awards = $148,626

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The genomic and synaptic basis of language disorder and learned sound association

Award Number: F31DC022183

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 09/01/2024

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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