Friday, December 27, 2024 12/27/2024

Investigating alterations in gustatory neuron innervation and function over the course of chemotherapy treatment

Award Number: F31DC021875
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

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Abstract Chemotherapy treatment frequently results in taste alterations that significantly impact patients' quality of life and recovery. While transient loss of taste receptor cells (TRCs) has been observed in mice after chemotherapy, this does not fully explain the prolonged taste disruptions reported by human patients. My preliminary data indicates that gustatory fiber innervation in taste buds is reduced shortly after chemotherapy, but the recovery of these connections and their effects on taste response remain unclear. This study aims to investigate the timeline of gustatory fiber recovery after cyclophosphamide (CYP) treatment and assess the strength and specificity changes in taste signaling. To determine the time course of gustatory fiber reinnervation within taste buds after CYP treatment, I will use immunohistochemistry and intravital imaging to monitor the recovery of gustatory fibers and taste synapses over 20+ days post-treatment. To assess the degree to which cyclophosphamide alters the strength and specificity of taste signaling in mice, I will use whole-nerve recording and in-vivo calcium imaging. This proposal is designed to unravel the recovery process of gustatory fiber innervation after chemotherapy and explore strength and specificity changes in taste signaling. In addition, activities planned for this proposal will strengthen my career development and training to achieve my goal of becoming a leader in investigating neuro-immune interactions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $40,594 )
2025	2025	THE UNIVERSITY OF TEXAS AT SAN ANTONIO	1 UTSA CIR	SAN ANTONIO	TX	78249	BEXAR	USA	Research Related to Deafness and Communication Disorders	000	2	11/25/2024	NON-COMPETING CONTINUATION	$40,594
														Subtotal = $40,594

Issue Date FY: 2024 ( Subtotal = $40,594 )
2024	2024	THE UNIVERSITY OF TEXAS AT SAN ANTONIO	1 UTSA CIR	SAN ANTONIO	TX	78249	BEXAR	USA	Research Related to Deafness and Communication Disorders	001	1	12/13/2023	NEW	$0
2024	2024	UNIVERSITY OF TEXAS AT SAN ANTONIO, THE	1 UTSA CIRCLE	SAN ANTONIO	TX	78249	BEXAR	USA	Research Related to Deafness and Communication Disorders	000	1	12/13/2023	NEW	$39,314
2024	2024	THE UNIVERSITY OF TEXAS AT SAN ANTONIO	1 UTSA CIR	SAN ANTONIO	TX	78249	BEXAR	USA	Research Related to Deafness and Communication Disorders	002	1	4/24/2024	NEW	$1,280
														Subtotal = $40,594

Grand Total All Awards = $81,188

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Investigating alterations in gustatory neuron innervation and function over the course of chemotherapy treatment

Award Number: F31DC021875

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

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