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Characterizing Changes to Event-Related Potentials and Neural Oscillations in the Auditory Cortex Following Inactivation of Parvalbumin and Somatostatin Interneurons.

Award Number: F31DC019856
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 04/01/2022
PERIOD OF PERFORMANCE END DATE: 03/31/2024

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Characterizing Changes to Event-Related Potentials and Neural Oscillations in the Auditory Cortex Following Inactivation of Parvalbumin and Somatostatin Interneurons. - Project Summary/Abstract The proposed study will identify interneuron subtypes that regulate the auditory event-related potential (ERP) and neural oscillatory activity in the auditory cortex. The ERP is widely-used to identify translationally relevant biomarkers and to characterize sensory deficits implicated in autism spectrum disorders, aging and hearing loss. However, the cortical circuit mechanisms that underlie the ERP are unknown. Functional deficits in GABAergic interneurons, namely parvalbumin-positive (PV) and somatostatin-positive (SOM) neurons, have been suggested in shaping ERP changes. PV and SOM neurons play a role in regulating the gain of stimulus-related responses and synchrony of neural responses in the cortex. However, the impact of altered PV and SOM neuron function on the ERP and neural oscillations in the auditory cortex remains poorly understood. The proposed study will integrate electrophysiology and chemogenetic techniques in order to directly manipulate the activity of PV and SOM neurons in the auditory cortex (AC) and characterize changes to the ERP and to neural oscillations. We will inject an adeno-associated virus (AAV) carrying Cre-dependent designer receptors exclusively activated by designer drugs (DREADD) into the AC of PV-Cre and SOM-Cre mice. Following recovery mice will receive systemic injections of the DREADD ligand clozaping-n-oxide or vehicle and auditory cortical activity will be recorded as mice are awake and freely moving in a sound-insulated arena where sound stimuli will be presented to them. We will record resting EEG and ERP and characterize changes in gamma and beta frequencies in the resting EEG and changes in ERP amplitude and latency during PV and SOM cell inactivation compared to control. The goal of this study is to generate novel insights into how interneuron dysfunction leads to altered sensory responses.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$1,219 )
2025	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	200 UNIVERSTY OFC BUILDING	RIVERSIDE	CA	92521	RIVERSIDE	USA	Research Related to Deafness and Communication Disorders	000	2	1/23/2025	NON-COMPETING CONTINUATION	-$1,219
														Subtotal = -$1,219

Issue Date FY: 2023 ( Subtotal = $42,302 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	200 UNIVERSTY OFC BUILDING	RIVERSIDE	CA	92521	RIVERSIDE	USA	Research Related to Deafness and Communication Disorders	000	2	3/22/2023	NON-COMPETING CONTINUATION	$42,302
														Subtotal = $42,302

Issue Date FY: 2022 ( Subtotal = $41,360 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	900 UNIVERSITY AVE	RIVERSIDE	CA	92521	RIVERSIDE	USA	Research Related to Deafness and Communication Disorders	002	1	4/25/2022	NEW	$717
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	900 UNIVERSITY AVE	RIVERSIDE	CA	92521	RIVERSIDE	USA	Research Related to Deafness and Communication Disorders	003	1	5/19/2022	NEW	-$1
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	900 UNIVERSITY AVE	RIVERSIDE	CA	92521	RIVERSIDE	USA	Research Related to Deafness and Communication Disorders	000	1	12/23/2021	NEW	$40,644
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE	900 UNIVERSITY AVE	RIVERSIDE	CA	92521	RIVERSIDE	USA	Research Related to Deafness and Communication Disorders	001	1	12/23/2021	NEW	$0
														Subtotal = $41,360

Grand Total All Awards = $82,443

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Characterizing Changes to Event-Related Potentials and Neural Oscillations in the Auditory Cortex Following Inactivation of Parvalbumin and Somatostatin Interneurons.

Award Number: F31DC019856

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 04/01/2022

PERIOD OF PERFORMANCE END DATE: 03/31/2024

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