Wednesday, October 1, 2025 10/1/2025

Dopaminergic modulation of NMDA receptor signaling in the Nucleus Accumbens

Award Number: F31DA064363
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 01/06/2026

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Dopaminergic modulation of NMDA receptor signaling in the Nucleus Accumbens - Project Summary Alterations in both dopamine (DA) and glutamate signaling in the Nucleus Accumbens (NAc) are thought to play a key role in substance use disorders and addiction. DA regulates NAc circuit activity by modulating glutamatergic transmission and receptor activity, however, the precise mechanisms remain unclear. Synaptic plasticity and regulation of intracellular excitability is primarily attributed to the functions of glutamatergic NMDA recept ors (NMDARs). How dopamine receptors regulate NMDAR activity and how this differs between synaptic connections in accumbal circuitry remain important questions. This proposal will utilize ex vivo slice electrophysiology in combination with optogenetics and iontophoresis in transgenic mouse lines to investigate the synapse specificity and intracellular signaling mechanisms underlying DA receptor regulation of NMDAR current in both D1 and D2 type dopamine receptors. Understanding the synergistic role of D1 and D2 receptor signaling in regulating glutamate transmission and receptor activity in the NAc is a critical step in the investigation of both motivation and the dysfunctions that arise in this system after exposure to drugs of abuse.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $41,270 )
2025	2025	THE REGENTS OF THE UNIV. OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Drug Use and Addiction Research Programs	000	1	7/7/2025	NEW	$41,270
														Subtotal = $41,270

Grand Total All Awards = $41,270

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Dopaminergic modulation of NMDA receptor signaling in the Nucleus Accumbens

Award Number: F31DA064363

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 01/06/2026

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