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Role of sleep disruption in cognitive impairment associated with methamphetamine use

Award Number: F31DA060673
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 04/02/2024
PERIOD OF PERFORMANCE END DATE: 04/01/2027

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Role of sleep disruption in cognitive impairment associated with methamphetamine use - Project Abstract Methamphetamine use and abuse are on the rise. Patients seeking treatment for methamphetamine use disorder often experience cognitive deficits and an increased incidence of sleep disturbances. Of note, it is well known that sleep impairment can negatively impact cognition, suggesting that methamphetamine-induced sleep disruption may be a key factor mediating the cognitive problems observed in methamphetamine users. Because individuals experiencing cognitive or sleep problems have poorer treatment outcomes and a greater likelihood of relapse, addressing sleep and cognitive impairments associated with methamphetamine use may be a novel approach to improving treatment outcomes. Based on these observations, the working hypothesis of this application is that methamphetamine-induced cognitive deficits are mediated by the effects of methamphetamine on sleep. Our research strategy is organized around two Specific Aims. Aim 1 will evaluate the prediction that acute sleep impairment induced by methamphetamine leads to cognitive deficits in drug naïve monkeys. Male and female rhesus monkeys will be given methamphetamine alone, methamphetamine plus the sleep aid suvorexant, or suvorexant alone the day before cognitive tests (CANTAB) evaluating executive functioning (intra-extra dimensional set-shifting task) and working memory (delayed matching-to-sample task). Aim 2 will evaluate the prediction that chronic methamphetamine self-administration induces greater cognitive deficits than acute administration, which will be mediated by methamphetamine-induced sleep disruption. Monkeys will be trained to self-administer methamphetamine (i.v.), and CANTAB cognition tests will be conducted after one month of methamphetamine taking, methamphetamine taking + evening suvorexant treatments, or food taking + evening suvorexant. Throughout Aim 1 and Aim 2 studies, sleep will be evaluated using actigraphy. Results from the proposed studies will provide key information regarding the extent to which methamphetamine-induced sleep disruptions contribute to the cognitive problems experienced by methamphetamine users, and the extent to which chronic drug use is necessary for cognitive impairments to emerge. Further, positive results with suvorexant will support the notion that treating drug-induced sleep problems may be a novel therapeutic strategy to improve patient outcomes, which would be particularly relevant for behavioral therapies that rely on intact cognitive function (e.g., cognitive behavioral therapy).


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $50,114 )
2026	2026	UNIVERSITY OF MISSISSIPPI MEDICAL CENTER	2500 N STATE ST	JACKSON	MS	39216	HINDS	USA	Drug Use and Addiction Research Programs	000	3	4/2/2026	NON-COMPETING CONTINUATION	$50,114
														Subtotal = $50,114

Issue Date FY: 2025 ( Subtotal = $49,538 )
2025	2025	UNIVERSITY OF MISSISSIPPI MEDICAL CENTER	2500 N STATE ST	JACKSON	MS	39216	HINDS	USA	Drug Use and Addiction Research Programs	001	2	7/22/2025	NON-COMPETING CONTINUATION	$564
2025	2025	UNIVERSITY OF MISSISSIPPI MEDICAL CENTER	2500 N STATE ST	JACKSON	MS	39216	HINDS	USA	Drug Use and Addiction Research Programs	000	2	3/25/2025	NON-COMPETING CONTINUATION	$48,974
														Subtotal = $49,538

Issue Date FY: 2024 ( Subtotal = $48,974 )
2024	2024	UNIVERSITY OF MISSISSIPPI MEDICAL CENTER	2500 N STATE ST	JACKSON	MS	39216	HINDS	USA	Drug Use and Addiction Research Programs	000	1	4/2/2024	NEW	$47,694
2024	2024	UNIVERSITY OF MISSISSIPPI MEDICAL CENTER	2500 N STATE ST	JACKSON	MS	39216	HINDS	USA	Drug Use and Addiction Research Programs	002	1	5/1/2024	NEW	$1,280
2024	2024	UNIVERSITY OF MISSISSIPPI MEDICAL CENTER	2500 N STATE ST	JACKSON	MS	39216	HINDS	USA	Drug Use and Addiction Research Programs	001	1	4/2/2024	NEW	$0
														Subtotal = $48,974

Grand Total All Awards = $148,626

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Role of sleep disruption in cognitive impairment associated with methamphetamine use

Award Number: F31DA060673

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 04/02/2024

PERIOD OF PERFORMANCE END DATE: 04/01/2027

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