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Influence of fear conditioning prior to cocaine self-administration on cocaine seeking in adult rats: assessing the role of the frontostriatal circuits in trauma and cocaine use co-occurrence

Award Number: F31DA060039
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 07/01/2024
PERIOD OF PERFORMANCE END DATE: 06/30/2025

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Influence of fear conditioning prior to cocaine self-administration on cocaine seeking in adult rats: assessing the role of the frontostriatal circuits in trauma and cocaine use co-occurrence - PROJECT SUMMARY Research has shown a high prevalence of trauma-related disorders and substance use disorder (SUD) co- occurrence. However, the mechanisms by which a traumatic event increases the vulnerability to SUD development and relapse are unknown. It is known that the prelimbic cortex (PL) and nucleus accumbens (NAc) core play critical roles in trauma-related disorders and SUD, but the neurophysiological changes caused in these structures by trauma and cocaine exposure are not fully understood. This proposal aims to dissect the mechanism by which a traumatic experience and cocaine exposure alter PL and NAc core communication in ways that may increase vulnerability to cocaine use disorder development. The hypothesis is that a traumatic event and cocaine exposure will cause neurophysiological changes in PL-NAc core synapses, resulting in increased drug-seeking behavior. To test the hypothesis, we will assess the effects of fear conditioning (FC) as a traumatic event, and cocaine exposure on cocaine-seeking behavior in male and female rats. Also, we will analyze the synaptic changes of the PL-projecting neurons to the NAc core, using whole cell patch-clamp electrophysiological recordings with optogenetic manipulation (Aim 1), as well as the influence of PL inactivation on cocaine seeking (Aim 2) from cocaine-exposed rats with or without FC. Preliminary behavioral data show that FC prior to cocaine exposure increases cue-primed reinstatement and cocaine-primed reinstatement in male rats, providing a suitable behavioral paradigm for investigating the neurophysiological changes that occur in this comorbidity. The findings of the proposed study will provide insight into how PL modulates the NAc core neurons in the presence of a traumatic experience and drug exposure, to influence drug-seeking behavior.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	PONCE MEDICAL SCHOOL FOUNDATION INC	388 CALLE LUIS F SALA	PONCE	PR	00716	PONCE	USA	Drug Use and Addiction Research Programs	000	1	5/5/2025	TERMINATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $39,552 )
2024	2024	PONCE MEDICAL SCHOOL FOUNDATION INC	388 CALLE LUIS F SALA	PONCE	PR	00716	PONCE	USA	Drug Use and Addiction Research Programs	000	1	5/29/2024	NEW	$39,552
2024	2024	PONCE MEDICAL SCHOOL FOUNDATION INC	388 CALLE LUIS F SALA	PONCE	PR	00716	PONCE	USA	Drug Use and Addiction Research Programs	001	1	5/29/2024	NEW	$0
														Subtotal = $39,552

Grand Total All Awards = $39,552

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Influence of fear conditioning prior to cocaine self-administration on cocaine seeking in adult rats: assessing the role of the frontostriatal circuits in trauma and cocaine use co-occurrence

Award Number: F31DA060039

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 07/01/2024

PERIOD OF PERFORMANCE END DATE: 06/30/2025

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