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Characterization of Polysubstance Use: Combined Fentanyl and Methamphetamine

Award Number: F31DA057815
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 02/01/2023
PERIOD OF PERFORMANCE END DATE: 06/19/2026
AWARD TERMINATION DATE: 10/20/2026

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Characterization of Polysubstance Use: Combined Fentanyl and Methamphetamine - Project Summary The opioid epidemic currently affecting the United States has entered a new wave of mortality, with combined use of opioid and psychomotor simulants as a major contributing factor to the number of overdose deaths. Combined use of fentanyl and methamphetamine may be due to a number of factors, including greater rewarding effects, decreased negative side effects, and/or feelings that combined use is somehow ‘safer’ than use of fentanyl alone. For those reasons, there is a clear need to examine the differences in the behavioral and neurobiological alterations that occur following chronic use of fentanyl, methamphetamine, and these two substances in combination. My preliminary findings suggest that there is enhanced hypodopaminergia following combined use of fentanyl and methamphetamine (COMBO) when compared to fentanyl use alone. I have determined that 1) in both male and female rats, elicited DA release was decreased in COMBO animals compared to fentanyl alone animals and; (2) male COMBO animals had greater response rates and responded more on a progressive ratio schedule of reinforcement. Therefore, this study aims to investigate the scarcely studied combination of fentanyl and methamphetamine via a three-pronged approach examining behavioral and neurobiological alterations to the DA system through self-administration, microdialysis and fast scan cyclic voltammetry, and the use of the novel photosensor dLight during behavioral responding. Collectively, the proposed aims will provide insight into the neurobiological and behavioral differences elicited by combined use of fentanyl and methamphetamine, an under-studied topic that is highly relevant for the current state of the opioid epidemic in the United States.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2027 ( Subtotal = -$18,047 )
2027	2026	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	000	4	10/20/2026	TERMINATION	-$18,047
														Subtotal = -$18,047

Issue Date FY: 2026 ( Subtotal = $50,114 )
2026	2026	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	001	4	3/24/2026	NON-COMPETING CONTINUATION	$576
2026	2026	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	000	4	1/28/2026	NON-COMPETING CONTINUATION	$49,538
														Subtotal = $50,114

Issue Date FY: 2025 ( Subtotal = $49,538 )
2025	2025	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	000	3	12/20/2024	NON-COMPETING CONTINUATION	$48,974
2025	2025	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	001	3	9/2/2025	NON-COMPETING CONTINUATION	$564
														Subtotal = $49,538

Issue Date FY: 2024 ( Subtotal = $48,974 )
2024	2024	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	001	2	5/2/2024	NON-COMPETING CONTINUATION	$1,280
2024	2024	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	000	2	1/12/2024	NON-COMPETING CONTINUATION	$47,694
														Subtotal = $48,974

Issue Date FY: 2023 ( Subtotal = $47,694 )
2023	2023	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	000	1	1/11/2023	NEW	$46,752
2023	2023	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	002	1	2/7/2023	NEW	$942
2023	2023	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	001	1	1/11/2023	NEW	$0
														Subtotal = $47,694

Grand Total All Awards = $178,273

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Characterization of Polysubstance Use: Combined Fentanyl and Methamphetamine

Award Number: F31DA057815

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 02/01/2023

PERIOD OF PERFORMANCE END DATE: 06/19/2026

AWARD TERMINATION DATE: 10/20/2026

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