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Smoking-related Differences in Baroreflex Sensitivity and Fear Inhibition in Adults Who Do and Do Not Smoke Cigarettes

Award Number: F31DA056207
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 07/01/2023
PERIOD OF PERFORMANCE END DATE: 06/30/2025

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Smoking-related Differences in Baroreflex Sensitivity and Fear Inhibition in Adults Who Do and Do Not Smoke Cigarettes - PROJECT SUMMARY/ABSTRACT Evidence that anxious smokers experience lower cessation success and account for a greater proportion of tobacco-related disease and disability underscores the need to identify common factors that underlie this comorbidity and improve outcomes in this vulnerable population. Research initiatives addressing cigarette use and anxiety have largely overlooked physiological mechanisms that facilitate body-brain communication, despite their promise as malleable intervention targets. To address this gap, study designs are needed that characterize (1) the effects of cigarette use on physiological processes that support body-brain communication and (2) how these impairments confer anxiety risk in human models. This application proposes that the baroreflex, a well-delineated feedback loop through which body-brain communication occurs, is likely to be impaired in cigarette smokers and, as a result, may undermine core learning processes that confer anxiety risk. The proposed study will involve a single in-person laboratory visit during which 66 participants (n=33 smokers; n=33 non-smokers) will complete a fear conditioning paradigm while baroreflex function assessed. Dependent variables include: (1) baroreflex function indexed via electrocardiograph and blood pressure data and (2) fear inhibition indexed via skin conductance response during the paradigm’s extinction training phase. Analysis of variance, linear regression, and mediation modeling will be used to examine group differences in baroreflex function between smokers and non-smokers (Aim 1), the relationship between baroreflex function and fear inhibition (Aim 2), and the direct and indirect effects of smoking status on fear inhibition through the baroreflex (Aim 3), respectively. Findings will refine knowledge of physiological processes implicated in anxiety, smoking, and their high comorbidity. The applicant is applying for an F31 award to receive high caliber training in the design and implementation of mechanism-focused addiction research (Goal 1), translational models of anxiety pathology (Goal 2), psychophysiological interpretation and analysis (Goal 3), and professional development (Goal 4). The research and training plan will lay the foundation for the applicant’s future line of research to examine how substance- related impairments in physiological function promote anxiety risk and maintain substance use behavior. Receiving an F31 fellowship will relieve the applicant from her time-intensive teaching assistant position to effectively to conduct research and establish a strong interdisciplinary network in the addiction science field.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$2,554 )
2026	2024	RUTGERS, THE STATE UNIVERSITY	3 RUTGERS PLZ	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	2	4/22/2026	NON-COMPETING CONTINUATION	-$2,554
														Subtotal = -$2,554

Issue Date FY: 2024 ( Subtotal = $47,181 )
2024	2024	RUTGERS, THE STATE UNIVERSITY	3 RUTGERS PLZ	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	2	6/14/2024	NON-COMPETING CONTINUATION	$47,181
														Subtotal = $47,181

Issue Date FY: 2023 ( Subtotal = $45,487 )
2023	2023	RUTGERS, THE STATE UNIVERSITY	3 RUTGERS PLZ	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Drug Use and Addiction Research Programs	002	1	7/10/2023	NEW	$0
2023	2023	RUTGERS, THE STATE UNIVERSITY	3 RUTGERS PLZ	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Drug Use and Addiction Research Programs	001	1	2/17/2023	NEW	$0
2023	2023	RUTGERS, THE STATE UNIVERSITY	3 RUTGERS PLZ	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Drug Use and Addiction Research Programs	000	1	2/17/2023	NEW	$45,487
														Subtotal = $45,487

Grand Total All Awards = $90,114

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Smoking-related Differences in Baroreflex Sensitivity and Fear Inhibition in Adults Who Do and Do Not Smoke Cigarettes

Award Number: F31DA056207

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 07/01/2023

PERIOD OF PERFORMANCE END DATE: 06/30/2025

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