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Proximal Antecedents and Subjective Effects of Cannabis Use and their Relation to Cannabis Use Disorder: An Ecological Momentary Assessment of Medical Cannabis Users

Award Number: F31DA049432
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 06/01/2020
PERIOD OF PERFORMANCE END DATE: 06/30/2021

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Proximal Antecedents and Subjective Effects of Cannabis Use and their Relation to Cannabis Use Disorder: An Ecological Momentary Assessment of Medical Cannabis Users - PROJECT SUMMARY More and more US states are legalizing cannabis for medical purposes, and the growing popularity of medical cannabis has outpaced scientific understanding of its benefits and harms. The most commonly reported reason for using medical cannabis is chronic pain. However, for the vast majority of medical cannabis users with chronic pain, the proximal antecedents of cannabis use, and the health benefits and risks of use, are unknown. This is because the best available evidence that pain triggers medical cannabis use is based on retrospective reports that are subject to problems of recall bias, and the best available evidence that medical cannabis alleviates pain, with few adverse side effects, is based on clinical trials that lack external validity. Clinical trials lack external validity because the types of cannabis administered bear little resemblance to medical dispensary cannabis, and because the sterile lab environments of clinical trials bear little resemblance to real-world settings. Therefore, research on the proximal antecedents and subjective effects of medical cannabis calls for measurement in the natural ecology. This project will examine proximal antecedents and acute effects of cannabis use in medical users’ natural environments. It will explore an array of possible antecedents of cannabis use among medical users, including pain but also negative affect and cannabis withdrawal – a symptom of cannabis use disorder (CUD). Because research shows that the prevalence of CUD is elevated among medical cannabis users, research is needed to understand mechanisms that might underlie the transition from medical cannabis use to CUD. Contemporary models of addiction posit that subjective states during periods of acute abstinence and subjective drug effects are key mechanisms in addiction development and maintenance. However, it is not known if and how the proximal antecedents and subjective effects of cannabis use relate to CUD severity among medical users. If medical cannabis causes a high or alleviates pain and negative affect in the everyday lives of medical users, for example, it is important to know whether these effects are associated with CUD severity. This information will bolster the development of safer and more effective treatment options. To address gaps in existing knowledge, the current proposal will use ecological momentary assessment (EMA) in a group of young-adult medical cannabis users to examine three specific aims: (1) Characterize the proximal antecedents of cannabis use in the daily lives of young-adult medical cannabis users; (2) characterize the acute subjective effects of cannabis in the daily lives of young-adult medical cannabis users; and (3) test whether the proximal antecedents and subjective effects of medical cannabis use vary as a function CUD severity. This information will help patients, physicians, and policymakers to make evidence-based decisions about the pros and cons of whether to use/recommend cannabis for medical purposes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$26,320 )
2023	2021	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Drug Use and Addiction Research Programs	001	2	11/23/2022	NON-COMPETING CONTINUATION	-$20,253
2023	2020	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Drug Use and Addiction Research Programs	000	1	11/23/2022	NEW	-$6,067
														Subtotal = -$26,320

Issue Date FY: 2021 ( Subtotal = $20,253 )
2021	2021	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Drug Use and Addiction Research Programs	001	2	6/9/2021	NON-COMPETING CONTINUATION	-$25,783
2021	2021	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Drug Use and Addiction Research Programs	000	2	5/14/2021	NON-COMPETING CONTINUATION	$46,036
														Subtotal = $20,253

Issue Date FY: 2020 ( Subtotal = $45,520 )
2020	2020	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Drug Use and Addiction Research Programs	001	1	3/30/2020	NEW	$0
2020	2020	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Drug Use and Addiction Research Programs	000	1	3/30/2020	NEW	$45,520
														Subtotal = $45,520

Grand Total All Awards = $39,453

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Proximal Antecedents and Subjective Effects of Cannabis Use and their Relation to Cannabis Use Disorder: An Ecological Momentary Assessment of Medical Cannabis Users

Award Number: F31DA049432

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 06/01/2020

PERIOD OF PERFORMANCE END DATE: 06/30/2021

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