Tuesday, July 1, 2025 7/1/2025

Role of glycosylated RNAs in Acute Myeloid Leukemia

Award Number: F31CA298737
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 07/01/2025
PERIOD OF PERFORMANCE END DATE: 06/30/2028

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Role of glycosylated RNAs in Acute Myeloid Leukemia - Project Summary/Abstract Acute myeloid leukemia (AML) is a malignant blood disorder characterized by the accumulation of immature myeloid progenitors at the expense of differentiated progeny. Despite the genetic heterogeneity of AML and clinical treatments, there persists a common focus on enhancing clinical outcomes and in comprehending the signaling mechanisms that allow for AML maintenance. The recent discovery glycosylated RNAs (glycoRNAs), RNA molecules post-transcriptionally modified with sialylated-N glycans, has upended our traditional understanding of RNA biology. Collaborator data has demonstrated cell surface glycoRNAs can serve as a signaling mechanism between myelomonocytic cell types. Given this information, the goal for this proposal is to characterize and define the role of glycoRNAs in acute myeloid leukemia. The first aim will characterize glycoRNA expression and sequences in distinct AML subtypes with those from normal myeloid progenitors. The second aim will define the role of Sidt proteins in AML glycoRNA expression and the third aim will determine the functions of glycoRNAs in AML biology as it pertains to AML development in vivo, regulating leukemic cell homing, and migratory capacity. Successful execution of these aims will provide valuable insight on the expression, regulatory mechanism, and function of glycoRNAs in AML. Completion of this work will provide significant advancements, potentially leading to novel clinical therapies for AML.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $49,538 )
2025	2025	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Research Manpower	000	1	1/28/2025	NEW	$48,974
2025	2025	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Research Manpower	001	1	1/28/2025	NEW	$0
2025	2025	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Research Manpower	002	1	6/4/2025	NEW	$564
														Subtotal = $49,538

Grand Total All Awards = $49,538

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Role of glycosylated RNAs in Acute Myeloid Leukemia

Award Number: F31CA298737

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 07/01/2025

PERIOD OF PERFORMANCE END DATE: 06/30/2028

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