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Differentiation and function of transitional monocytes in cancer metastasis to the lung

Award Number: F31CA284549
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 09/28/2023
PERIOD OF PERFORMANCE END DATE: 12/31/2025

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Differentiation and function of transitional monocytes in cancer metastasis to the lung - Project Summary/Abstract Cancer metastasis occurs when cancer cells spread to distal organs from their site of origin, and it is the leading cause of death in patients with solid cancers. When cancer spreads to the lung, various types of innate immune cells either help or inhibit this colonization process. Monocytes are one of the earliest cell types to flood the lung during the beginning of metastasis. These monocytes eventually become tumor-supporting metastasis-associated macrophages (MAMs), and many studies in the field have reported that monocytes and MAMs actively aid metastatic cancer to infiltrate the lung and take residence there. My project aims to understand how monocytes differentiate into MAMs; in particular, what signals and factors are critical for this transition to occur in the lung. Furthermore, from my preliminary data, I have identified a time window during which monocytes have undergone clear phenotypic changes but have not yet fully developed into MAMs. Interestingly, this transition period also coincides with the anti-tumor activity of other immune cell types, such as natural killer (NK) cells. Therefore, I aim to study the interactions between pro-tumoral monocytes and anti- tumoral NK cells during the first several hours of cancer metastasis to the lung. By understanding how the mechanisms that underlie these interactions help to increase the odds of metastatic establishment in the lung, I will be able to contribute valuable insights towards novel therapeutic efforts to prevent metastasis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2027 ( Subtotal = -$40 )
2027	2025	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Cancer Research Manpower	000	3	10/27/2026	NON-COMPETING CONTINUATION	-$40
														Subtotal = -$40

Issue Date FY: 2025 ( Subtotal = $23,456 )
2025	2025	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Cancer Research Manpower	000	3	8/15/2025	NON-COMPETING CONTINUATION	$23,456
														Subtotal = $23,456

Issue Date FY: 2024 ( Subtotal = $44,483 )
2024	2024	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Cancer Research Manpower	000	2	8/15/2024	NON-COMPETING CONTINUATION	$44,483
														Subtotal = $44,483

Issue Date FY: 2023 ( Subtotal = $43,203 )
2023	2023	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Cancer Research Manpower	000	1	7/27/2023	NEW	$43,203
2023	2023	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Cancer Research Manpower	001	1	7/27/2023	NEW	$0
														Subtotal = $43,203

Grand Total All Awards = $111,102

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Differentiation and function of transitional monocytes in cancer metastasis to the lung

Award Number: F31CA284549

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 09/28/2023

PERIOD OF PERFORMANCE END DATE: 12/31/2025

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