Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Exploring the Impact of Genetic Ancestry on Acute Lymphoblastic Leukemia Risk in Latino Populations

Award Number: F31CA278359
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 12/01/2023
PERIOD OF PERFORMANCE END DATE: 11/30/2027

Group Awards By:

View Award Description

Exploring the Impact of Genetic Ancestry on Acute Lymphoblastic Leukemia Risk in Latino Populations - The objective of this proposal is to employ and refine state-of-the-art gene discovery methods to uncover the genetic etiology of Acute Lymphoblastic Leukemia (ALL) risk and to leverage genetic admixture to identify new risk loci relevant to all human populations. Over the past few decades, incidence of ALL has increased on both a global and national scale. While strides in treatment of ALL, especially in children, have been made, the cure rate for children with high-risk subtypes and adults remains staggeringly low. Consequently, investigations into the etiology of the disease, with the overall aim of identifying new risk factors and designing new intervention and prevention strategies, is of clear importance. Previous literature has suggested an immunological and genetic etiology to ALL risk, with exposures such as early childhood infections and risk alleles at known lymphocyte development genes modulating risk. Further, genetic epidemiological studies have suggested that different genetic backgrounds may harbor genetic alleles that contribute to risks in individuals from the Americas. Our study thus presents a unique opportunity to use the historical admixture for ancestry-aware gene- and fine- mapping strategies, with the goal of uncovering genetic loci associated with the disease across populations. This proposed project seeks to tandemly elucidate the etiology of elevated ALL risk across different populations and add to the tools for genetic studies in admixed populations. Using over 3000 cases and 9000 controls from large population-based case-control and clinical trial studies, Ms. Langie will implement and develop gene discovery methods tailored to admixed populations to identify novel risk loci and causal genes associated with ALL. Given the overarching hypothesis that genetic ancestry from Americas may harbor population-enriched risk alleles associated with risk of ALL, Ms. Langie will implement a form of association testing that includes estimated local ancestry in the model and produces ancestry-specific effect sizes (Aim 1A). Furthermore, she will conduct admixture mapping and specifically test for the effect of genetic ancestry in ALL risk both locally and across the genome (Aim 1B). She will then perform multi-ethnic fine-mapping and gene-prioritization analysis at known and novel (discovered from Aim1) risk ALL loci to nominate plausible biological candidates for downstream functional and pharmacological investigations (Aim 2). Finally, she will develop a new method in admixture mapping that combines different study designs of admixture mapping studies to improve upon both the power and robustness of current designs (Aim 3).


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $49,538 )
2026	2026	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Cancer Research Manpower	000	3	12/10/2025	NON-COMPETING CONTINUATION	$49,538
														Subtotal = $49,538

Issue Date FY: 2025 ( Subtotal = $49,538 )
2025	2025	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Cancer Research Manpower	000	2	1/14/2025	NON-COMPETING CONTINUATION	$48,774
2025	2025	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Cancer Research Manpower	002	2	8/19/2025	NON-COMPETING CONTINUATION	$764
2025	2025	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Cancer Research Manpower	001	2	2/13/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $49,538

Issue Date FY: 2023 ( Subtotal = $47,694 )
2023	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Cancer Research Manpower	001	1	4/12/2023	NEW	$0
2023	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Cancer Research Manpower	000	1	4/12/2023	NEW	$47,694
														Subtotal = $47,694

Grand Total All Awards = $146,770

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Exploring the Impact of Genetic Ancestry on Acute Lymphoblastic Leukemia Risk in Latino Populations

Award Number: F31CA278359

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 12/01/2023

PERIOD OF PERFORMANCE END DATE: 11/30/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer