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Function of DNA translocases in telomere replication

Award Number: F31CA189375
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 07/03/2014
PERIOD OF PERFORMANCE END DATE: 07/02/2017

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Function of DNA translocases in telomere replication - DESCRIPTION (provided by applicant): With each round of replication, billions of DNA bases must be replicated accurately and completely to yield two identical copies of the genome that eventually result in two daughter cells. There are several obstacles to this process including damage from endogenous or exogenous sources, nucleotide depletion, and hard-to-replicate sequences in the DNA. Telomeres are repetitive, highly structured hard-to-replicate DNA sequences that cap the ends of chromosomes to prevent inappropriate DNA damage signaling. To ensure complete replication of the genome, a mechanism to resolve the structured DNA and promote replication through telomeres must exist. Our preliminary data indicates that the DNA damage response protein SMARCAL1 (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A-like1) acts as a component of this general pathway to promote genomic stability at telomeres. I hypothesize that SMARCAL1 is essential for telomere maintenance and regulation. To investigate this essential function of SMARCAL1, I propose two aims: (1) to fully characterize the extent of this novel SMARCAL1 function at telomeres and (2) to identify the mechanism of Smarcal1 localization to telomeres. I will combine genetic and biochemical approaches to complete these aims. Through the completion of these studies, I will participate in multiple training activities to prepare for a career as an independent research scientist.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = -$8,174 )
2021	2016	VANDERBILT UNIVERSITY, THE	2301 VANDERBILT PL	NASHVILLE	TN	37235	DAVIDSON	USA	Cancer Research Manpower	000	3	1/7/2021	NON-COMPETING CONTINUATION	-$8,174
														Subtotal = -$8,174

Issue Date FY: 2016 ( Subtotal = $28,233 )
2016	2016	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Research Manpower	000	3	6/17/2016	NON-COMPETING CONTINUATION	$28,233
														Subtotal = $28,233

Issue Date FY: 2015 ( Subtotal = $36,211 )
2015	2015	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Research Manpower	000	2	6/12/2015	NON-COMPETING CONTINUATION	$36,211
														Subtotal = $36,211

Issue Date FY: 2014 ( Subtotal = $42,676 )
2014	2014	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Research Manpower	000	1	7/3/2014	NEW	$0
2014	2014	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Research Manpower	001	1	7/3/2014	NEW	$42,676
														Subtotal = $42,676

Grand Total All Awards = $98,946

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Function of DNA translocases in telomere replication

Award Number: F31CA189375

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 07/03/2014

PERIOD OF PERFORMANCE END DATE: 07/02/2017

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