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MINORITY PREDOCTORAL FELLOWSHIP PROGRAM

Award Number: F31CA113269
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 09/30/2004
PERIOD OF PERFORMANCE END DATE: 09/29/2009

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MINORITY PREDOCTORAL FELLOWSHIP PROGRAM - DESCRIPTION (provided by applicant): Immunotherapy using complement activating antibodies specific for tumor antigens has not yielded satisfactory results in the clinic. Complement inhibitors expressed on tumor cells (often at elevated levels) promote tumorigenesis and are an important factor in the resistance of tumor cells to antibody-mediated immunotherapy. We hypothesize that downregulation of the expression of complement inhibitory proteins on the surface of tumor cells will increase sensitivity of tumor cells to anti-MUCI (a bladder cancer associated antigen) antibody-mediated immunotherapy and may also enhance the outcome of a normally ineffective immune response. It is proposed to use a clinically relevant syngeneic MUC1 transgenic model of bladder cancer to investigate the role of complement inhibitors in tumor immunity and in the resistance of tumor cells to anti-MUC1 antibody therapy in the context of immune sufficiency, tolerance and autoimmunity. The expression of complement inhibitors will be modulated by RNAi. The proposed studies have the potential to lead to the development of new immunotherapy strategies for the treatment of bladder cancer


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2008 ( Subtotal = $34,291 )
2008	2008	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Research Manpower	000	5	8/28/2008	NON-COMPETING CONTINUATION	$34,291
														Subtotal = $34,291

Issue Date FY: 2007 ( Subtotal = $34,857 )
2007	2007	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Research Manpower	000	4	9/12/2007	NON-COMPETING CONTINUATION	$34,857
														Subtotal = $34,857

Issue Date FY: 2006 ( Subtotal = $35,841 )
2006	2006	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Research Manpower	000	3	9/5/2006	NON-COMPETING CONTINUATION	$35,841
														Subtotal = $35,841

Issue Date FY: 2005 ( Subtotal = $36,986 )
2005	2005	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Research Manpower	000	2	9/7/2005	NON-COMPETING CONTINUATION	$36,986
														Subtotal = $36,986

Issue Date FY: 2004 ( Subtotal = $34,933 )
2004	2004	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Research Manpower	000	1	9/16/2004	NEW	$34,933
														Subtotal = $34,933

Grand Total All Awards = $176,908

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MINORITY PREDOCTORAL FELLOWSHIP PROGRAM

Award Number: F31CA113269

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 09/30/2004

PERIOD OF PERFORMANCE END DATE: 09/29/2009

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