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Physiological Outcomes of Mind-Body Health Practices for Stress-Related Disorders

Award Number: F31AT011469
ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 05/01/2022
PERIOD OF PERFORMANCE END DATE: 06/30/2023

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Physiological Outcomes of Mind-Body Health Practices for Stress-Related Disorders - Project Summary Heightened cardiovascular reactivity to acute stressors is a common symptom of posttraumatic stress (PTS). Integrative mind-body health practices have shown promise for the treatment of PTS and stress-related disorders. Many of these integrative practices include pranayam, the practice of controlled breathing. Mind-body practices often use a type of pranayam that emphasizes slowed, deep breathing, as a strategy to calm physiological stress reactions. Pranayam has yet to be studied as an isolated, acute coping response when confronted with trauma reminders. Little is known about how well this strategy actually works to calm one’s hyperarousal symptoms, particularly elevated cardiovascular reactivity. Pranayam has been explored generally as a method of calming the stress response, though not in the context of trauma and not isolated as a coping strategy for managing acute distress. Identifying effective methods to calm cardiovascular responses to trauma reminders is important given the association of exaggerated cardiovascular reactivity with later risk for cardiovascular disease. For this project, we examine 1) how effective pranayam is at reducing hyperarousal in response to trauma reminders, both in spontaneous daily use and in a directed lab task, 2) whether higher levels of interoceptive awareness increase the effect that pranayam has on lowering hyperarousal reactions, 3) if emotion regulation skills mediate the relationship between pranayam use and cardiovascular reactivity. We are conducting this study within a sample of 130 female sexual trauma survivors. We will compare pranayam to a cognitive-based coping strategy, cognitive reappraisal, to determine if pranayam is an effective means of calming trauma cue-induced hyperarousal. Hyperarousal will be determined by cardiovascular measures of arousal, including heart rate, heart rate variability, and blood pressure. By isolating and explicitly testing deep breathing pranayam, we can determine if pranayam is the mechanism through which mind-body health interventions may exert their effects. This simple, parsimonious strategy can be emphasized as a primary coping strategy for survivors who may have limited time or few available resources. This project serves as a training vehicle through which the applicant can work towards her long-term research goals of examining how integrative mind-body health interventions may impact the stress response in trauma-exposed populations. This project is the next phase of the applicant’s broader career research goal of identifying and understanding the mechanisms through which mind-body interventions can reduce cardiovascular risk, particularly for trauma survivors who are at increased risk for cardiovascular disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$19,088 )
2024	2023	UNIVERSITY OF CONNECTICUT	438 WHITNEY RD EXTENSION UNIT 1133	STORRS	CT	06269	CAPITOL	USA	Research and Training in Complementary and Integrative Health	000	2	4/24/2024	NON-COMPETING CONTINUATION	-$19,088
														Subtotal = -$19,088

Issue Date FY: 2023 ( Subtotal = $22,799 )
2023	2023	UNIVERSITY OF CONNECTICUT	438 WHITNEY RD EXTENSION UNIT 1133	STORRS	CT	06269	CAPITOL	USA	Research and Training in Complementary and Integrative Health	000	2	4/19/2023	NON-COMPETING CONTINUATION	$47,694
2023	2023	UNIVERSITY OF CONNECTICUT	438 WHITNEY RD EXTENSION UNIT 1133	STORRS	CT	06269	CAPITOL	USA	Research and Training in Complementary and Integrative Health	001	2	9/20/2023	NON-COMPETING CONTINUATION	-$24,895
														Subtotal = $22,799

Issue Date FY: 2022 ( Subtotal = $46,752 )
2022	2022	UNIVERSITY OF CONNECTICUT	438 WHITNEY RD EXTENSION UNIT 1133	STORRS	CT	06269	CAPITOL	USA	Research and Training in Complementary and Integrative Health	000	1	4/1/2022	NEW	$46,036
2022	2022	UNIVERSITY OF CONNECTICUT	438 WHITNEY RD EXTENSION UNIT 1133	STORRS	CT	06269	CAPITOL	USA	Research and Training in Complementary and Integrative Health	002	1	6/16/2022	NEW	$716
2022	2022	UNIVERSITY OF CONNECTICUT	438 WHITNEY RD EXTENSION UNIT 1133	STORRS	CT	06269	CAPITOL	USA	Research and Training in Complementary and Integrative Health	001	1	4/1/2022	NEW	$0
														Subtotal = $46,752

Grand Total All Awards = $50,463

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Physiological Outcomes of Mind-Body Health Practices for Stress-Related Disorders

Award Number: F31AT011469

ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 05/01/2022

PERIOD OF PERFORMANCE END DATE: 06/30/2023

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