Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Neural and Psychosocial Predictors of Pain Trajectories in Youth

Award Number: F31AR088609
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 09/09/2026
PERIOD OF PERFORMANCE END DATE: 09/08/2028

Group Awards By:

View Award Description

Neural and Psychosocial Predictors of Pain Trajectories in Youth - PROJECT SUMMARY Chronic pain affects an estimated 20% of youth, the majority of whom will continue to have pain persist into adulthood [1-4]. Pediatric pain is related to increased risk for long-term disability, comorbid mental health conditions, and suicidality [5-8]. While the brain is increasingly recognized as a central driver of many chronic pain conditions, the specific neural circuitry underlying the development of persistent pain in youth remains poorly understood. Neuroimaging research has identified widespread structural and functional brain differences between youth with and without pain, but findings have been inconsistent and largely limited to small, clinically homogenous samples [10]. The few existing studies of youth pain in large, community samples have focused on specific pain types and parent-reported outcomes, rather than examining predictors of youth self-reported general pain characteristics [11-13]. A critical gap remains in understanding the neural circuitry and psychosocial risk factors underlying self-reported pain experiences in adolescence, particularly in large-scale epidemiological cohorts. Leveraging these cohorts is critical for providing the statistical power needed to identify generalizable brain markers of adolescent pain, and to uncover malleable risk factors of pain before chronicity[14]. This proposal seeks to identify biopsychosocial predictors of pain persistence in a large community sample (N = 7,712) of youth from the Adolescent Brain Cognitive Development Study. The specific aims are as follows: (Aim 1) identify naturally occurring subgroups of adolescents with distinct three-year pain trajectories using latent class growth analysis; (Aim 2) examine whether gray-matter volume and resting-state functional connectivity predict pain trajectories using ridge-penalized multinomial logistic regression; and (Aim 3) determine whether clinically modifiable psychosocial factors predict pain trajectories using ridge-penalized multinomial logistic regression, and test, in a hypothesis-driven manner, whether they moderate associations between brain-based predictors and pain outcomes using multinomial logistic regression. By integrating longitudinal pain data with multimodal neuroimaging and psychosocial measures, this project endeavors to elucidate risk factors that shape pain trajectories during adolescence. The proposed study will ultimately yield clinically translatable insights by identifying biopsychosocial targets to inform intervention and prevention strategies for persistent pain in youth.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $50,114 )
2026	2026	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	1	9/16/2026	NEW	$0
2026	2026	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	9/9/2026	NEW	$50,114
														Subtotal = $50,114

Grand Total All Awards = $50,114

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Neural and Psychosocial Predictors of Pain Trajectories in Youth

Award Number: F31AR088609

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 09/09/2026

PERIOD OF PERFORMANCE END DATE: 09/08/2028

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer