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Establishing the Mechanisms of Antiretroviral Induced Osteoporosis and Obesity

Award Number: F31AR088599
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 09/17/2026
PERIOD OF PERFORMANCE END DATE: 09/16/2028

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Establishing the Mechanisms of Antiretroviral Induced Osteoporosis and Obesity - Project Summary/Abstract Antiretroviral therapy (ART) effectively suppresses HIV infection but continues to contribute to long-term comorbidity risks, including osteoporosis and obesity. In this fellowship training proposal, I will examine how two commonly prescribed antiretrovirals, tenofovir disoproxil fumarate (TDF) and tenofovir alafenamide (TAF), reshape bone-fat hormonal crosstalk through pathways that affect bone and adipose tissue structure and function. The central hypothesis is that TDF and TAF differentially regulate osteoblast and adipocyte activity and alter the production of bone- and fat-derived hormones that coordinate skeletal and metabolic responses. To address this central hypothesis, I will utilize a novel humanized mouse model (Specific Aim 1) and in vitro cell culture models (Specific Aim 2) to evaluate bone and adipose tissue changes at the cellular, tissue, and organ levels and to gain translational and mechanistic insight. Together, these approaches will provide a mechanistic framework for understanding how ART influences communication between bone and adipose tissue and why two closely related medications lead to different comorbidity risks. Throughout the proposal period, I will also gain technical training in the use of humanized mouse models and detailed characterization of tissue and cellular level changes in bone and adipose tissue, including use of unbiased techniques. I will collaborate with my sponsor and mentoring committee to prepare for my independent research career by focusing on scientific communication and further training in statistical analyses. The long-term significance of this work is to guide strategies that minimize skeletal and metabolic complications associated with specific treatments and support healthier aging in people with HIV and provide me with the necessary skills to build an independent research career.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2027 ( Subtotal = $0 )
2027	2026	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	10/5/2026	NEW	$0
														Subtotal = $0

Issue Date FY: 2026 ( Subtotal = $50,114 )
2026	2026	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	9/17/2026	NEW	$50,114
														Subtotal = $50,114

Grand Total All Awards = $50,114

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Establishing the Mechanisms of Antiretroviral Induced Osteoporosis and Obesity

Award Number: F31AR088599

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 09/17/2026

PERIOD OF PERFORMANCE END DATE: 09/16/2028

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