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MINORITY PREDOCTORAL FELLOWSHIP PROGRAM

Award Number: F31AR053373
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 09/26/2005
PERIOD OF PERFORMANCE END DATE: 09/25/2009

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MINORITY PREDOCTORAL FELLOWSHIP PROGRAM - DESCRIPTION (provided by applicant): Tissue engineering can be defined as the application of biological, chemical and engineering principles towards the development of biological substitutes for the repair or restoration of tissue function. This approach offers the possibility of replacing damaged or injured bone tissue with engineered constructs that can be used for guided bone regeneration. In this proposal, a tissue engineering approach will be investigated for the development of a novel, surface-modified, polymer system for use as an osteoinductive, biodegradable scaffold for the replacement of human bone grafts. This system involves the use of 2-dimensional (2-D), amino-acid alkyl ester containing polyphosphazenes (PPHOS) that will be surface modified by covalently attaching osteoinductive peptides to enhance the cellular responsiveness of osteoblasts and bone marrow derived stem cells. Covalently immobilized, osteoinductive peptides will be presented to cells on the surface of these polymeric scaffolds in efforts to enhance osteoblast cell differentiation and support new bone growth. Various tests will be performed to characterize the surface physico-chemical properties of the matrix as well as its in vitro osteoinductive properties and in vivo bone forming potential. The specific aims of this proposal include: 1) Covalently immobilizing osteoinductive oligopeptide sequences to the surface of amino acid alkyl ester-containing PPHOS and characterizing their surface physico-chemical properties, 2) Characterizing the osteoinductive potential of and cellular responsiveness to surfacemodified PPHOS using in vitro techniques, and 3) Evaluating the biocompatibility and bone forming potential of surface-modified PPHOS using in vivo techniques.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2009 ( Subtotal = $0 )
2009	2008	UNIVERSITY OF CONNECTICUT HEALTH CENTER	263 FARMINGTON CENTER	FARMINGTON	CT	06032	CAPITOL	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	5	8/17/2009	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2009	2008	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	4	10/13/2008	NON-COMPETING CONTINUATION	-$54,545
2009	2008	UNIVERSITY OF CONNECTICUT HEALTH CENTER	263 FARMINGTON CENTER	FARMINGTON	CT	06030	CAPITOL	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	5	10/13/2008	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$54,545
														Subtotal = $0

Issue Date FY: 2008 ( Subtotal = $54,545 )
2008	2008	UNIVERSITY OF VIRGINIA	PO BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	4	8/7/2008	NON-COMPETING CONTINUATION	$54,545
														Subtotal = $54,545

Issue Date FY: 2007 ( Subtotal = $49,904 )
2007	2007	UNIVERSITY OF VIRGINIA	PO BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	8/6/2007	NON-COMPETING CONTINUATION	$49,904
														Subtotal = $49,904

Issue Date FY: 2006 ( Subtotal = $47,352 )
2006	2006	UNIVERSITY OF VIRGINIA	PO BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	8/16/2006	NON-COMPETING CONTINUATION	$47,352
														Subtotal = $47,352

Issue Date FY: 2005 ( Subtotal = $46,311 )
2005	2005	UNIVERSITY OF VIRGINIA	PO BOX 9003	CHARLOTTESVILLE	VA	22906	CHARLOTTESVILLE CITY	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	7/4/2005	NEW	$46,311
														Subtotal = $46,311

Grand Total All Awards = $198,112

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MINORITY PREDOCTORAL FELLOWSHIP PROGRAM

Award Number: F31AR053373

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 09/26/2005

PERIOD OF PERFORMANCE END DATE: 09/25/2009

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