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Determining the Regulators of Immunoglobulin Secretion: Integrated Training in Immunology and RNA Biology

Award Number: F31AI200328
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 11/23/2026
PERIOD OF PERFORMANCE END DATE: 11/22/2027

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Determining the Regulators of Immunoglobulin Secretion: Integrated Training in Immunology and RNA Biology - PROJECT SUMMARY Changes in 3’ end processing of RNA are implicated in many diseases, including several malignancies. A highly conserved hexameric polyadenylation signal sequence (PAS) directs processing machinery where to cleave nascent RNA to add a polyA tail and is central to the mechanism by which 3’ ends are processed. The transcript coding for antibodies contains two terminal exons that code for a transmembrane domain, which is flanked by two PAS, one encoding membrane Ig (mIg), and the other encoding secreted (sIg). We hypothesize Ig is regulated by trans-acting factors that either interact directly with Ig RNA or change the transcriptional landscape of the cells. Using RAP-MS2.0, a method developed in our lab we have identified 80 proteins conserved between mouse and human B cells that interact directly with Ig RNA. We intend to validate these interactions using biochemical methods to map the interactions and functional genomics (Aim I). To understand how the transcriptional landscape contributes to APA in B cells, we will use a reporter-based, high throughput screen of TFs to identify regulators of the mIg to sIg transition. (Aim II). Through these complementary aims, we expect to identify the factors that mediate this mechanism at the crux of autoimmunity and cancer. Furthermore, the central product of this grant is my interdisciplinary training as a graduate student, which involves multi-layered mentoring to promote my growth towards an academic career with categorical focus on disciplinary, professional, and pedagogical development.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $45,057 )
2026	2026	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT STREET	BURLINGTON	VT	05405	CHITTENDEN	USA	Allergy and Infectious Diseases Research	000	1	5/25/2026	NEW	$45,057
														Subtotal = $45,057

Grand Total All Awards = $45,057

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Determining the Regulators of Immunoglobulin Secretion: Integrated Training in Immunology and RNA Biology

Award Number: F31AI200328

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 11/23/2026

PERIOD OF PERFORMANCE END DATE: 11/22/2027

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