Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Utilizing biochemical and functional genomic approaches to uncover key host invasion receptors in Plasmodium vivax

Award Number: F31AI197660
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 09/27/2026
PERIOD OF PERFORMANCE END DATE: 09/26/2027

Group Awards By:

View Award Description

Utilizing biochemical and functional genomic approaches to uncover key host invasion receptors in Plasmodium vivax - PROJECT SUMMARY/ABSTRACT Malaria parasites infect red blood cells (RBCs), within which they proliferate to cause disease in a continuous cycle of invasion, growth, and egress from one host RBC to another. Free merozoite forms of the parasite use ligand-receptor interactions to invade RBCs within which they grow and proliferate. Plasmodium vivax, a major parasite species that causes malaria in humans, exclusively invades reticulocytes, the youngest of RBCs, through specific ligand-receptor interactions. The Duffy antigen receptor for chemokines (DARC), a blood group antigen on the RBC surface, was the first identified essential receptor for P. vivax and is bound by the parasite invasion protein P. vivax Duffy Binding Protein (PvDBP). PvDBP is now a major vaccine candidate, but it is known that P. vivax uses multiple receptors to invade host cells, known as invasion pathways, that are poorly understood. Here, I propose to identify essential reticulocyte host receptors for P. vivax invasion using biochemical and functional studies. This work is based on the CRISPR/Cas9-based manipulation of RBC membrane proteins. The identification of essential ligand-receptor interactions for P. vivax invasion is crucial for informing the development of therapeutic interventions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $49,721 )
2026	2026	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE STE 3	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Allergy and Infectious Diseases Research	001	1	4/2/2026	NEW	$576
2026	2026	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE STE 3	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Allergy and Infectious Diseases Research	000	1	3/27/2026	NEW	$49,145
														Subtotal = $49,721

Grand Total All Awards = $49,721

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Utilizing biochemical and functional genomic approaches to uncover key host invasion receptors in Plasmodium vivax

Award Number: F31AI197660

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 09/27/2026

PERIOD OF PERFORMANCE END DATE: 09/26/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer