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A nanocoating for continuous disinfection of frequently touched surfaces

Award Number: F31AI169954
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 12/01/2022
PERIOD OF PERFORMANCE END DATE: 08/31/2024

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A nanocoating for continuous disinfection of frequently touched surfaces - A nanocoating for continuous disinfection of frequently touched surfaces Healthcare-associated infections (HAIs) represent a constant risk for patients and healthcare workers and have a large impact on public health. Fomites, inanimate surfaces contaminated by pathogens, are a passive source of infection and their role in infection propagation in hospitals has been recognized as an important health problem. Fomites can be contaminated with microbes by direct contact with body fluids such as blood or saliva or by airborne microbial particles, like sneeze droplets. In the nosocomial setting, noncritical frequently touched surfaces (FTS) such as doorknobs, countertops, bedrails, and bedside tables may contribute to fomite-mediated HAIs by contaminating the hands of health care providers or by contact with medical equipment that will subsequently come in contact with patients. To prevent and reduce the risk of HAIs transmission, the low-level disinfection (LLD) of FTS is a widely used strategy. LLD aims to inactivate vegetative bacteria, virus, and fungi, but not spores. To do so, liquid disinfectants or wipes are used to wet the surface for the amount of time recommended by the manufacturer, usually 10 minutes or less. LLD has been found to be highly effective (>4- log10 reduction) in removing/inactivating epidemiologically important pathogens. Nevertheless, since recontamination can occur at any moment after cleaning, an important drawback of LLD is the need for repeated disinfectant application. To address this, here we propose the use of a nanocoating (NC) for continuous LLD of FTS. The NC will be able to attain >4-log10 reduction of gram positive and gram-negative bacteria in 15 minutes or less by using visible light to kill pathogens via oxidative stress. It will be formulated for an environmental- friendly application and will keep its antibacterial activity for about 60 days. The specific aims to reach the objective are: AIM 1. Formulation and optimization of NCs. The material will be formulated and optimized for high bacterial reduction (>4-log10) in 15 min or less against S. aureus and E. coli. AIM 2. Characterization and optimization of NC properties. The mechanical, physiochemical, and antibacterial properties of new and aged coatings will be assessed to optimize performance and duration. AIM 3. In vitro and in vivo studies to assess the safeness of NCs. Studies using human cells and animal models will be performed to evaluate adverse health effects of NCs.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$8,978 )
2025	2024	UNIVERSITY OF TEXAS AT ARLINGTON	701 S NEDDERMAN DR	ARLINGTON	TX	76019	TARRANT	USA	Allergy and Infectious Diseases Research	001	2	7/25/2025	NON-COMPETING CONTINUATION	-$1,922
2025	2024	UNIVERSITY OF TEXAS AT ARLINGTON	701 S NEDDERMAN DR	ARLINGTON	TX	76019	TARRANT	USA	Allergy and Infectious Diseases Research	000	2	1/14/2025	NON-COMPETING CONTINUATION	-$7,056
														Subtotal = -$8,978

Issue Date FY: 2024 ( Subtotal = $40,462 )
2024	2024	UNIVERSITY OF TEXAS AT ARLINGTON	701 S NEDDERMAN DR	ARLINGTON	TX	76019	TARRANT	USA	Allergy and Infectious Diseases Research	001	2	5/15/2024	NON-COMPETING CONTINUATION	$1,280
2024	2024	THE UNIVERSITY OF TEXAS AT ARLINGTON	701 S. NEDDERMAN DR	ARLINGTON	TX	76019	TARRANT	USA	Allergy and Infectious Diseases Research	000	2	11/17/2023	NON-COMPETING CONTINUATION	$39,182
														Subtotal = $40,462

Issue Date FY: 2022 ( Subtotal = $38,240 )
2022	2022	THE UNIVERSITY OF TEXAS AT ARLINGTON	701 S. NEDDERMAN DR	ARLINGTON	TX	76019	TARRANT	USA	Allergy and Infectious Diseases Research	000	1	8/19/2022	NEW	$38,240
														Subtotal = $38,240

Grand Total All Awards = $69,724

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A nanocoating for continuous disinfection of frequently touched surfaces

Award Number: F31AI169954

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 12/01/2022

PERIOD OF PERFORMANCE END DATE: 08/31/2024

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