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Development and application of subnational measles incidence and mortality estimates in high burden and incidence settings

Award Number: F31AI167535
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 09/01/2022
PERIOD OF PERFORMANCE END DATE: 01/24/2024

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Development and application of subnational measles incidence and mortality estimates in high burden and incidence settings - Project Summary/Abstract Vaccination against measles has been available for decades, although still a substantial number of global cases and deaths persist. Strategies to reach measles elimination goals require a more comprehensive understanding of the patterns of immunity and burden across space, time and age in local contexts throughout the world, particularly in low- and middle-income countries. These challenges, in part, can be addressed via a thorough examination of all available data on measles immunity, cases, and deaths and synthesizing these data streams through the development of novel mathematical and statistical models, particularly on subnational scales. This proposal will first quantify global measles immunity patterns via a systematic search of all available seroprevalence studies and catalytic modeling to describe patterns by location and age. Next, we will estimate subnational measles incidence in the six highest burden countries using case notifications, serology data, and subnational vaccine coverage estimates. Then, to assess local areas with highest measles mortality, we will estimate subnational case-fatality using all available literature and spatially available covariates. Finally, we will assess the economic and health benefits of subnationally-targeted immunization strategies over a nationally based approach. This project will investigate global measles immunity and mortality patterns at national and subnational scales, as well as evaluate the cost-effectiveness of subnational targeting of various vaccination strategies. The goal of this research is to provide empirical evidence for global stakeholders and local decision makers to plan informed immunization efforts as well as measles control and elimination programing. After the completion of this research and training fellowship, the applicant will have acquired advanced skills in spatiotemporal and statistical modeling, infectious disease and vaccination epidemiology, economic evaluation, scientific communication, and classroom teaching. The applicant seeks expertise in these fields in order to advance measles eradication and control efforts and to improve the overall understanding the role of subnational analyses and estimates in optimizing disease control and local health initiatives. A multidisciplinary and collaborative team will mentor and guide the applicant in research and training and assist in preparing the applicant for an academic career in infectious disease and vaccine epidemiology and mathematical modeling, with a focus on producing timely and policy-relevant research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$35,829 )
2025	2023	REDACTED DUE TO PII		LONDON				GBR	Allergy and Infectious Diseases Research	002	2	11/27/2024	NON-COMPETING CONTINUATION	-$9,477
2025	2023	LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE	KEPPEL STREET	LONDON				GBR	Allergy and Infectious Diseases Research	000	2	11/27/2024	NON-COMPETING CONTINUATION	$0
2025	2022	REDACTED DUE TO PII		LONDON				GBR	Allergy and Infectious Diseases Research	001	1	11/27/2024	NEW	-$26,352
														Subtotal = -$35,829

Issue Date FY: 2024 ( Subtotal = -$19,942 )
2024	2023	REDACTED DUE TO PII		LONDON				GBR	Allergy and Infectious Diseases Research	002	2	7/31/2024	NON-COMPETING CONTINUATION	$0
2024	2023	LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE	KEPPEL STREET	LONDON				GBR	Allergy and Infectious Diseases Research	001	2	5/23/2024	NON-COMPETING CONTINUATION	-$2,275
2024	2023	REDACTED DUE TO PII		LONDON				GBR	Allergy and Infectious Diseases Research	000	2	5/23/2024	NON-COMPETING CONTINUATION	-$17,667
														Subtotal = -$19,942

Issue Date FY: 2023 ( Subtotal = $46,353 )
2023	2023	LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE	KEPPEL STREET	LONDON				GBR	Allergy and Infectious Diseases Research	001	2	8/17/2023	NON-COMPETING CONTINUATION	$19,209
2023	2023	REDACTED DUE TO PII		LONDON				GBR	Allergy and Infectious Diseases Research	000	2	8/16/2023	NON-COMPETING CONTINUATION	$27,144
														Subtotal = $46,353

Issue Date FY: 2022 ( Subtotal = $45,411 )
2022	2022	LONDON SCHOOL OF HYGIENE & TROPICAL MEDICINE	KEPPEL ST	LONDON				GBR	Allergy and Infectious Diseases Research	001	1	9/2/2022	NEW	$19,059
2022	2022	REDACTED DUE TO PII		LONDON				GBR	Allergy and Infectious Diseases Research	000	1	9/1/2022	NEW	$26,352
														Subtotal = $45,411

Grand Total All Awards = $35,993

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Development and application of subnational measles incidence and mortality estimates in high burden and incidence settings

Award Number: F31AI167535

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 09/01/2022

PERIOD OF PERFORMANCE END DATE: 01/24/2024

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